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2002 JAN 17 - (NewsRx.com & NewsRx.net) -- Lifetime exposure to hormone replacement therapy (HRT) may be associated with better maintenance of cognitive function in older women free of dementia, according to a new study.
More than 2000 women, age 65 and older, participated in the collaborative study, conducted by investigators at Johns Hopkins University, Utah State University, Duke University Medical Center, and the University of California, San Francisco.
Study participants were assessed using a cognitive measure, the Modified Mini-Mental State Exam (3MS), and a simplified version of the depression section of the Diagnostic Interview Schedule. They also provided demographic and occupational information, psychiatric and medical history, and lifestyle information. These women, all from Cache County, Utah, were followed for three years to assess changes in cognition and depression status and additionally provided detailed information regarding use of HRT.
"This study shows an apparent benefit of lifetime HRT use on cognitive function in nondemented older women," according to study coauthor Michelle C. Carlson, PhD, of Johns Hopkins University. Study findings of the effects apparent with HRT use are clinically as well as statistically significant. "And ...