AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Antisense Iron-Responsive Element Targets Breast Cancer Cells.
2002 JAN 17 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Investigators at the M.D. Anderson Cancer Center may have devised a new way to target breast cancer cells that express a potent cancer gene.
"Overexpression of HER-2/neu proto-oncogene is found in many human cancers including 20% to 30% of breast cancer and is a predictor of poor prognosis," said investigator Z. Li, University of Texas, and the coauthors of a recent report.
Armed with knowledge about antisense (AS) complexes and the inhibitory properties of iron-responsive elements (IREs), which are known to block translation by binding to endogenous iron regulatory protein (IRP), Li and colleagues developed and tested three AS-IREs, labeled 1, 4, and 5, with the potential for suppressing HER-2/neu proto-oncogene expression. In vitro, each of the AS-IREs blocked translation when placed into the 5' untranslated region of a reporter gene.
"Using AS-IRE4 as our model, we demonstrated that it is regulated by iron, and importantly, such regulation is impaired in HER-2/neu-overexpressing breast cancer cells," reported Li and associates.
That same molecule was also drawn to the reporter gene of breast cancer cells that overly produced HER-2/neu, and researchers found it could guide reporter gene expression ...
- Stray breast cancer cells yield to post-op chemo; women with microscopic...
- News wire article from: Consumer Health News (English) Doheny, Kathleen August 12, 2009 700+ words
...surgically for early-stage breast cancer. They were divided into three...included 856 women diagnosed with breast cancer whose sentinel node -- the...included 856 women diagnosed with breast cancer with cancer cells found in the nodes, but who...
- Progestins Stimulate Growth Factor Production In Cancer Cells.(breast cancer)
- Magazine article from: Women's Health Weekly June 7, 2001 700+ words
...like progesterone, cause some breast cancer cells to produce a growth factor...increase the VEGF expression in breast cancer cells, making progestin inhibition...progesterone drug RU-486 to the breast cancer cells, indicating an important role...
- Grant received to study interaction between breast cancer cells and other cells.
- Newspaper article from: Cancer Weekly August 10, 2004 700+ words
...how the interaction between breast cancer cells and other cell types affect...stimulation of the estrogen dependent breast cancer cells, which is prevented by aromatase...cell-cell contact between breast cancer cells and surrounding cells. Knowledge...
- Marrow Can Hide Breast Cancer Cells.(Brief Article)
- Magazine article from: Science News Seppa, N. February 26, 2000 700+ words
...whom the initial breast cancer hadn't spread...100 who harbored cancer cells in bone marrow died...done routinely on breast cancer patients, Park...Currently, finding cancer cells in a breast cancer patient's lymph...
- PPAR gamma ligands and ATRA inhibit the invasion of breast cancer cells in...
- Newspaper article from: Drug Week June 20, 2003 700+ words
...gamma ligands and ATRA inhibit the invasion of breast cancer cells in vitro. According to a study from Germany...ligands and ATRA inhibit the invasion of human breast cancer cells in vitro. Breast Cancer Res Treat, 2003;79(1):63-74...
- Estrogen Found In Soy Stimulates Human Breast Cancer Cells In Mice.
- Magazine article from: Women's Health Weekly November 29, 2001 700+ words
...the growth of estrogen-dependent human breast-cancer cells implanted into laboratory mice. The findings...mice that lack the ability to reject human cancer cells. After inserting breast cancer cells, researchers were able to closely monitor...
- Estrogen Found In Soy Stimulates Human Breast Cancer Cells In Mice.(Brief...
- Newspaper article from: Cancer Weekly November 27, 2001 700+ words
...the growth of estrogen-dependent human breast-cancer cells implanted into laboratory mice. The findings...mice that lack the ability to reject human cancer cells. After inserting breast cancer cells, researchers were able to closely monitor...
- CD44 may confer the metastatic properties of breast cancer cells.
- Newspaper article from: Cancer Gene Therapy Week September 29, 2003 700+ words
...may confer the metastatic properties of breast cancer cells. According to a study from Japan...results showed the following features of breast cancer cells: 1) HGF stimulated breast cancer cells by upregulating CD44 expression in a concentration...
