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Immune Response Enhancer Improves Vaccine.(Brief Article)
2002 JAN 16 - (NewsRx.com & NewsRx.net) -- Antigenics, Inc., announced the publication of clinical results of a malaria vaccine containing Antigenics' immune response enhancer, QS-21, which showed significant protection against the most widespread and dangerous forms of malaria.
GlaxoSmithKline Biologicals (GSKB) is developing the vaccine for the treatment of malaria. Currently named RTS,S/AS02, it is produced by combining a malaria antigen with an adjuvant formulation that contains QS-21.
In the 250 men who completed the study in the Gambia, West Africa, the vaccine was found safe and immunogenic. It induced strong antibody responses to circumsporozoite protein and strong T-cell responses. This is the first preerythrocytic vaccine to show significant protection against natural P. falciparum.
The study, published in the December 8, 2001, issue of The Lancet, is titled "Efficacy of RTS,S/AS02 malaria vaccine against Plasmodium falciparum infection in semi-immune adult men in The Gambia: A randomized trial."
The effectiveness of QS-21 has been evaluated in approximately 50 Phase I, II, and III trials involving more than 3,000 patients. QS-21 has been shown to enhance the quality and quantity of the immune response to a variety of antigens including those associated with malaria. Specifically, in a study published in the New England Journal of Medicine, January 9, 1997, researchers from the Walter Reed Army ...
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