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Cross-Reactive Memory Cells Recognize HCV Peptides After Influenza Exposure.(Brief Article)
2002 JAN 16 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Vaccine developers need to keep in mind that cross-reactive memory cells can form in human hosts, producing an immune response to antigens the host has not previously been exposed to.
This happens because of antigen similarities. Researchers at the U.S. National Institutes of Health say they have observed such cross-reactions after studying the blood of healthy blood donors negative for HCV. Memory T cells were responsible for that cross-reactivity.
According to their data, a key determinant, the hepatitis C virus (HCV) (NS3-1073) peptide CVNGVCWTV, is often detected in patients infected with HCV. "Using a sensitive in vitro technique with HCV peptides and multiple cytokines, we were able to expand cytotoxic T cells specific for this determinant not only from the blood of 11 of 20 HCV-infected patients (55%), but also from the blood of 9 of 15 HCV-negative blood donors (60%)," H. Wedemeyer and colleagues of the NIH said.
Memory T cells from the healthy blood donors elicited a significant response and cross-reactivity to a unique determinant from the A/PR/8/34 influenza A virus (IV), the researchers noted (Cross-reactivity between hepatitis C virus and influenza A virus determinant-specific cytotoxic T cells, Journal of Virology, December 2001;75(23):11392-11400).
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Source: HighBeam Research, Cross-Reactive Memory Cells Recognize HCV Peptides After Influenza...