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Have You Seen The Little Piggies?(pigs engineered to provide organs for humans)(Brief Article)

Newsweek International

| January 14, 2002 | Beith, Malcolm | COPYRIGHT 2002 Newsweek, Inc. All rights reserved. Any reuse, distribution or alteration without express written permission of Newsweek is prohibited. For permission: www.newsweek.com. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

Biotech rivals bickered over a momentous milestone last week: the first cloned pigs genetically engineered to keep their organs from being rejected by human transplant recipients. Immerge BioTherapeutics Inc. had scheduled a Jan. 3 announcement of the event, which came on Sept. 21, but PPL Therapeutics stole its thunder by announcing a day earlier that its own litter of swine came into the world on Christmas Day.

In both cases, researchers "knocked out" the pig gene that sticks sugar molecules onto the surface of organs; the human immune system attaches to those sugars, recognizes the organ as foreign and rejects it. PPL's five little piggies and Immerge's original seven (four survive) could therefore be important ...

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