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Protein Blocks Cell Proliferation In Breast Tissue.(regultory protein kinase I-kappa-B)
2002 JAN 10 - (NewsRx.com & NewsRx.net) -- The discovery of a protein that blocks the proliferation of cells in breast tissue could be good news for future generations of breast cancer sufferers.
During pregnancy, breast epithelial cells undergo tremendous proliferation with the number of cells increasing over 10 times. After babies are weaned, these epithelial cells undergo programmed cell death, reverting the breast epithelium back to a nonpregnant state.
Many researchers think it's just this ability to proliferate so rapidly that predisposes cells in the breast to a high risk of cancer. So Michael Karin and colleagues at the University of California, San Diego, in La Jolla, investigated the role of a subunit (alpha) of a regulatory protein kinase complex called I-(kappa)-B kinase (or IKK) in breast tissue. Their study is reported the Dec. 14, 2001, issue of the ...
- New role for IKK seen in embryonic development of skull and skeleton.
- Newspaper article from: Biotech Week April 28, 2004 700+ words
...Continuing studies about an important regulatory protein kinase complex called I-kappa-B kinase (or IKK) have now shown that a subunit of IKK - IKK alpha - influences the outer layer of skin in developing mice to control the eventual shape of the...
- Novel IKK-2 Inhibitor Blocks Disease Progression in Preclinical Model of...
- Press release article from: PR Newswire November 14, 2001 700+ words
...of novel small molecule IkB kinase-2 (IKK-2) inhibitor CDC 839/AS602868. When...destruction. The data demonstrates that IKK-2 inhibitors may have significant disease...potential in treating rheumatoid arthritis. The IKK Signalsome(TM) controls the activation...
- IKK-2 Inhibitor Blocks Disease Progression In Preclinical Model.
- Newspaper article from: Drug Week December 14, 2001 700+ words
...small molecule I(kappa)B kinase-2 (IKK-2) inhibitor CDC 839/AS602868. When...destruction. The data demonstrates that IKK-2 inhibitors may have significant disease...potential in treating rheumatoid arthritis. The IKK Signalsome controls the activation of nuclear...
- When is enough, enough? IKK or Chillventa--either way a change is...
- Magazine article from: ASHRAE Journal December 1, 2006 700+ words
...Conditioning, Ventilation Trade Fair (IKK) left here better acquainted with the products...at Nuremberg in 2008 while the owners of IKK promoted Stuttgart as its 2008 home. Oh, and there will be a 2007 IKK event within the Aircontec section of ISH...
- Finding a missing link: scientists show a new connection between inflammation...
- Magazine article from: Science News Lock, C. August 21, 2004 700+ words
...protein called I-kappa-B kinase beta (IKK-beta) inside cells stops cancer progression in its tracks. IKK-beta normally plays a role in healing...injury, immune system molecules activate IKK-beta. Once stimulated, this protein keeps...
- Celgene Corporation Presents Data on Orally Available IKK-2 Inhibitor.
- Press release article from: PR Newswire September 24, 2001 700+ words
...Celgene's small molecule IkB kinase-2 (IKK-2) inhibitor, potently regulates the...and cancer. "We believe that our novel IKK-2 inhibitors represent an important new...multi-protein complex, the IkB kinase (IKK) Signalsome(TM), controls the activation...
- IKK-2 Inhibitor Has Anti-Inflammatory/Anticancer Potential.(Brief Article)
- Newspaper article from: Health & Medicine Week October 15, 2001 700+ words
...small molecule I(kappa)B kinase-2 (IKK-2) inhibitor, potently regulates the...and cancer. "We believe that our novel IKK-2 inhibitors represent an important new...multi-protein complex, the IkB kinase (IKK) Signalsome, controls the activation of...
- IKK 94 showcases worlds' hvacr products. (International Fair for Refrigerating...
- Magazine article from: Air Conditioning, Heating & Refrigeration News Stahl, Manfred January 30, 1995 700+ words
...the last of the three very successful exhibition days for IKK 94. (IKK is the Internationale Fachmesse Kalte-Klimatechnik...promoters and exhibitors was that the already 15-year-old IKK has strengthened its status as a leading exhibition for...
