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Resistant Genotypes Can Confound Research.(Brief Article)
2002 JAN 9 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Rhesus macaques with genotypes naturally resistant to the simian form of HIV can confound the results of HIV vaccine studies, researchers warn.
"Both vaccination- and infection-induced T-cell responses are dependent on the host major histocompatibility complex classes I and II (MHC-I and MHC-II) antigens," explained R. Pal and colleagues in a multicenter, international study that included Advanced BioScience Laboratories, Inc., and Aventis-Pasteur, Ltd.
Animals with cells that express the MHC-I antigen Mamu-A[superscript]*01 have an inherent resistance to SIV infection, which could create the illusion of vaccine efficacy, Pal and coauthors said.
They evaluated the efficacy of a recombinant canarypox-based vaccine with genes coding for the SIV proteins Gag, Pol, and Env (ALVAC-SIV-gpe). Administration of this vaccine to SIV-exposed rhesus macaques reduced viral loads and preserved CD4 cell counts, study data showed.
Mamu-A[superscript]*01[superscript]+ animals also maintained normal CD4 cell counts after SIV infection, even those who were not given the vaccine, the researchers said. Viral loads remained high in these macaques, however.
The presence of the Mamu-A[superscript]*01 antigen did not protect CD4 cell counts after exposure to ...
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