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Ridding Cells Of Heat Shock Protein 70 Enhances Tumor Immunogenicity.(Brief Article)
2002 JAN 9 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Researchers in France may have discovered a better way to produce immunity against colon cancer cells, leading the way for the development of new tumor vaccines.
S. Gurbuxani and colleagues, INSERM, Dijon, France, recently announced in Oncogene that using gene transfer techniques targeting the gene for heat shock protein 70(HSP70), researchers have caused rodent models to develop a cell-specific immune response to PRO colon cancer cells.
According to the researchers, HSP70 enhances immunogenicity in tumor cells, but at the same time, it keeps tumor cells from dying, disabling their ability to elicit immune response properly. By using antisense DNA, the group has made gains in defeating that problem.
"Stable transfection of an antisense HSP70 cDNA in PRO cells (PRO-70AS cells) strongly decreased HSP70 expression and sensitized cell-free extracts to cytochrome c/dATP-mediated activation of caspases," the INSERM team said.
Upon subcutaneous injection into nude mice, the transfected cells grew normally, but the same cells formed tumors which regressed in size when injected into syngeneic rats. Syngeneic rodents administered PRO cells after ...
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Source: HighBeam Research, Ridding Cells Of Heat Shock Protein 70 Enhances Tumor...