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Fibroblasts Useful Vectors For Gene Delivery After Surgical Injury.(Brief Article)
2002 JAN 9 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Fibroblasts, which tend to congregate at the sites of injuries, are useful vectors for gene delivery, scientists in Japan have determined.
It is not uncommon for cancers to recur at the site of surgical resection, scientists say. At the same time, fibroblasts, important for wound healing and tissue remodeling processes, are known to amass where surgery has been performed. A new study of surgery performed on rats suggests these fibroblasts could be instrumental for delivering tumor-specific genes to surgical sites, preventing tumor recurrence and speeding up healing activity.
Working at Kyoto University Graduate School of Medicine, W.G. Yang and colleagues performed a series of experiments with transfected fibroblasts, introducing the cells into rats with surgically induced intraperitoneal (i.p.) wounds made susceptible to tumor recurrence.
"We demonstrated that fibroblasts transfected with the GFP (green fluorescent protein) gene accumulated specifically around the site of injury immediately after i.p. injection," Yang and coworkers said.
A second set of experiments using fibroblasts transfected with ...
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- Radiation and tamoxifen after breast-conserving surgery reduce tumor recurrence.
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- Moffitt Neuro-Oncology Study of Wafer During Surgery Shows Zero Tumor...
- Press release article from: PR Newswire April 30, 2003 700+ words
...during tumor surgery, all patients remained free of tumor at the operative site. Historically in a group of this size, a tumor recurrence rate of at least 10 percent occurs. Steven Brem, M.D., leader of Moffitt's Neuro-Oncology Program, is announcing...
- Moffitt Center NeuroOncology Study of Wafer Implanted During Surgery Shows Zero...
- News wire article from: Europe Intelligence Wire April 30, 2003 700+ words
...during tumor surgery, all patients remained free of tumor at the operative site. Historically in a group of this size, a tumor recurrence rate of at least 10 percent occurs. Steven Brem, M.D., leader of Moffitt's Neuro-Oncology Program, is announcing...
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- News wire article from: Ascribe Higher Education News Service April 30, 2003 700+ words
...during tumor surgery, all patients remained free of tumor at the operative site. Historically in a group of this size, a tumor recurrence rate of at least 10 percent occurs. Steven Brem, M.D., leader of Moffitt's Neuro-Oncology Program, is announcing...
- Rescue Therapy Stems Tumor Recurrence.(skin cancer removal)(Brief Article)
- Magazine article from: USA Today (Magazine) February 1, 1999 700+ words
Mohs micrographic surgery is a specialized method of skin cancer removal considered to be the "rescue therapy" after other treatments fail. Experts in the procedure say patients should ask their dermatologist or family physician to consider it first instead of last in the treatment chain because,
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- Magazine article from: Neurology India Koutourousiou, Maria Georgakoulias, N. Kontogeorgos, G. Seretis, A. March 1, 2009 700+ words
Byline: Maria. Koutourousiou, N. Georgakoulias, G. Kontogeorgos, A. Seretis Subependymomas of the lateral ventricles are rare tumors. We present two patients with subependymomas of the lateral ventricle, who underwent gross total resection of the tumor via transcallosal approach. The patient, with
Source: HighBeam Research, Fibroblasts Useful Vectors For Gene Delivery After Surgical...