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Modified Rhabdovirus Makes Effective Vector.(Brief Article)
2002 JAN 9 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - A modified form of the rabies virus may be the foundation for an effective HIV vaccine, researchers in the United States say.
Heather D. Foley and colleagues at Thomas Jefferson University's Jefferson Medical College in Philadelphia and the George Washington University Medical Center in Washington, DC, described their recombinant rhabdovirus (RV) vector in the January 2002 edition of the Journal of Virology.
RV-based vectors were able to infect a number of different types of cells, including dendritic cells, they said.
Foley and coworkes constructed their vector by replacing the ectodomain and transmembrane domains of the rabies glycoprotein with the same domains from the HIV glycoprotein gp160. Vectors with envelope proteins from T cell- and dual-tropic strains of HIV were created, according to the report.
These recombinant viruses were highly infectious, able to invade a wide range of immune cells including peripheral blood mononuclear cells and both immature and mature dendritic cells. The ligand for CXCR4 and CD4 blocked infection by both virus vectors, study data showed, while CCR5's ligand only prevented infection by ...
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Source: HighBeam Research, Modified Rhabdovirus Makes Effective Vector.(Brief Article)