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Resistant African Sex Workers May Have Specific Antibody Responses.(Brief Article)
2001 DEC 26 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - African sex workers who become resistant to HIV infection can develop antibodies that target the virus in vaginal fluid, researchers say.
Prof. Laurent Belec and colleagues at INSERM Unit 430 at Broussais Hospital, Pierre and Marie Curie University, and Georges Pompidou European Hospital in Paris, France, Project RETRO-CI and the National Program for the Fight Against AIDS in Abidjan, Ivory Coast, and the U.S. Centers for Disease Control and Prevention in Atlanta, Georgia investigated antibody activity in persistently seronegative sex workers.
Some of these women demonstrated strong and compartmentalized HIV specific humoral responses, Belec and coauthors reported.
The researchers examined 342 African sex workers who remained HIV[superscript]- despite extensive exposure to the virus. HIV specific antibodies made up of immunoglobulin A (IgA), IgG, and IgM were found in cervicovaginal secretions (CVSs) from 7.5% of the women studied, as were elevated levels of the antiviral chemokine RANTES, they said.
Purified CVS antibodies prevented cell-associated HIV from traveling through cultured epithelial monolayers via transcytosis. The CVS antibodies targeted the HIV proteins gp160 and p24, study data showed.
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Source: HighBeam Research, Resistant African Sex Workers May Have Specific Antibody...