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Clumping Factor A Vaccination Effective Against Septic Arthritis.(Brief Article)
2001 DEC 26 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in the United States and England say that vaccination with a staphylococcal protein can help prevent staph-induced arthritis.
Dr. Elisabet Josefsson and colleagues at the University of Goteborg in Sweden, Trinity College in Dublin, Ireland, and the Alpharetta, Georgia-based pharmaceutical firm Inhibitex reported their findings on the "importance of the fibrinogen-binding adhesin clumping factor A (ClfA) in the pathogenesis of Staphylococcus aureus septic arthritis" in the December 15 edition of the Journal of Infectious Diseases.
Controlled exposure to ClfA reduced the severity of septic arthritis in animals, the researchers said.
They compared the virulence of a mutant staphylococcus strain with defective ClfA expression with that of wild-type S. aureus in mice. Mice infected with mutant staph developed much milder arthritic symptoms than those exposed to wild-type bacteria, study data showed.
Josefsson and team then treated mice with a vaccine made from recombinant ClfA. Immunized mice developed a milder form of arthritis after S. aureus ...
- Staphylococcal clumping factor A disrupts macrophage phagocytosis.
- Newspaper article from: Biotech Week June 2, 2004 700+ words
...net) -- Staphylococcal clumping factor A (ClfA) disrupts macrophage...infection models, e.g., of septic arthritis," rheumatologists in Sweden...Expression of staphylococcal clumping factor A impedes macrophage phagocytosis...
- Septic arthritis in patients with pre-existing inflammatory arthritis.(Case...
- Magazine article from: CMAJ: Canadian Medical Association Journal Kherani, Raheem B. Shojania, Kam May 22, 2007 700+ words
...superimposed infection? ********** Septic arthritis can be difficult to diagnosis, especially...arthritis in this review of nongonococcal septic arthritis. Septic arthritis in patients with rheumatoid arthritis was...
- PULSECLINICAL: Musculoskeletal Special Report - Septic arthritis.(Report)
- Newspaper article from: Pulse May 13, 2009 700+ words
...key signs and pitfalls in diagnosing septic arthritis Worst outcomes if missed * Death - septic arthritis is a life-threatening disease...The mortality for monoarticular septic arthritis is between 4% and 8%. * Poor joint...
- Pediatric Septic Arthritis.
- Magazine article from: AORN Journal SALZBACH, ROBIN December 1, 1999 700+ words
Acute septic arthritis (ie, septic joint) is a bacterial invasion...a 50% mortality rate for children with septic arthritis.(2) Fifty percent of the reported cases of septic arthritis occur in children less than three years...
- Clinical: Diagnosis and care of septic arthritis - the basics.
- Magazine article from: GP November 23, 2007 700+ words
A complete cure of septic arthritis can be achieved with prompt...referral, says Dr Harry Brown. Septic arthritis is an infection of the joint...produce good results, making septic arthritis one of the few forms of arthritis...
- Treatment of septic arthritis.(Letters)(Letter to the editor)
- Magazine article from: CMAJ: Canadian Medical Association Journal Main, Cheryl Kherani, Raheem B. Shojania, Kam October 9, 2007 700+ words
...provided a comprehensive overview of septic arthritis; however, I have some concerns about...regimen; it is a common cause of septic arthritis in patients at risk for sexually transmitted...least be considered when treating septic arthritis. Cheryl Main MD BSc Medical ...
- Septic arthritis of the ankle due to Salmonella enteritidis: a case...
- Magazine article from: Southern Medical Journal Meldrum, Russell Feinberg, Judy R. January 1, 2004 700+ words
Abstract: Salmonella septic arthritis in healthy individuals is a...Salmonella enteritidis, septic arthritis ********** Salmonella...causative agent in osteomyelitis septic arthritis (3-8) or as a postinfectious...
- No changes in the distribution of organisms responsible for septic arthritis...
- Magazine article from: Annals of the Rheumatic Diseases Dubost, JJ Soubrier, M De Champs, C Ristori, JM Bussiere, JL Sauvezie, B March 1, 2002 700+ words
...resistance of the pathogens responsible for septic arthritis over a 20 year period in patients...admitted between 1979 and 1998 for septic arthritis with positive microbiological diagnosis...or both. Results: 303 cases of septic arthritis were studied, 141 in the period 1979...
- Treatment of Septic Arthritis in Children.(Clinical report)
- Magazine article from: Infectious Disease Alert July 1, 2009 700+ words
Treatment of Septic Arthritis in Children Abstract &...randomized study of treatment of septic arthritis in children 3 months to 15 years...noninferiority trial of childhood septic arthritis was performed at seven referral...
- Sternoclavicular joint septic arthritis manifesting as a neck abscess: a case...
- Magazine article from: Ear, Nose and Throat Journal Mohyuddin, Atta August 1, 2003 700+ words
Abstract Septic arthritis of the sternoclavicular joint...uncommon disease. Introduction Septic arthritis of the sternoclavicular joint...case of sterno-clavicular joint septic arthritis. This case had some interesting...
Source: HighBeam Research, Clumping Factor A Vaccination Effective Against Septic...