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Breast Fluid May Mean Cancer Risk.(abnormal cells in breast fluid may double risk)
2001 DEC 27 - (NewsRx.com & NewsRx.net) -- Researchers who studied specimens from thousands of women suggest that the presence of abnormal cells in breast fluid may predict a doubled risk of breast cancer.
In a study appearing December 5, 2001, in the Journal of the National Cancer Institute, the researchers said that analyzing breast fluids extracted from nonpregnant and nonlactating women showed that those with abnormal cells were twice as likely to develop breast cancer.
Women from whom no fluid could be drawn, the study showed, had the lowest risk of breast cancer while those with normal cells in the fluid were at about a 60% higher risk.
"Our study shows that if you can get fluid from a woman and there are abnormal cells in that fluid, then it is an indication of increased risk of breast cancer," said Margaret R. Wrensch, an epidemiologist at the University of California, San Francisco, School of Medicine and the first author of the study. She said the study suggests, but does not prove, that when a woman who is not pregnant or nursing produces fluid, it may be an indication of increased risk.
"We think that some women have some fluid in their breast ducts all of the time," said Wrensch. "We don't understand...why we can obtain fluid from some women and not from others." She said the fluid could signal that there are changes underway in the breast.
Wrensch said the results of the study suggest that an analysis of breast fluid should be considered for inclusion on the list of factors that doctors now evaluate when predicting a woman's breast cancer risk. Other risk factors include close family members with breast cancer, age, genetic makeup, the results of physical examinations, and biopsies. She cautioned that further work is needed to determine how it would be used in routine patient care.
Dr. Bruce F. Kimler, a cancer specialist at the University of Kansas Medical Center in Kansas City, Kansas, urged caution in using cells from breast fluid as a predictor of breast cancer risk. He said the procedure to obtain ...
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