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Gene Gun Therapy Via Oral Mucosa Generates System-Wide Tumor Inhibition.(Brief Article)
2001 DEC 19 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - The oral mucosa may be best for some types of particle-mediated gene transfer.
After comparing various tissues for gene expression following cancer gene therapy, researchers in Japan suggested the oral mucosa expressed newly generated proteins better than most others did and induced better systemic distribution, signaling oral inoculation could be the best way to go about treating some cancer patients.
"In the study, we examined the efficacy of particle-mediated oral gene transfer on luciferase and green fluorescent protein production," said J. Wang and colleagues, Jichi Medical school, Tochigi, Japan. "The results showed that these proteins were more significantly expressed in oral mucosa than the skin, stomach, liver and muscle," they said.
In hamsters with oral melanoma, oral gene therapy with interleukin (IL)-12 complementary DNA (cDNA) inhibited tumor growth, increasing survival as well.
When oral IL-12 gene gun therapy was coadministered with an irradiated melanoma vaccine, melanoma growth in the skin was suppressed better than when percutaneous treatment was administered, revealing an advantage of oral ...
- Gene Gun Therapy Via Oral Mucosa Generates System-Wide Tumor Inhibition.
- Newspaper article from: Gene Therapy Weekly December 20, 2001 700+ words
...following cancer gene therapy, researchers...suggested the oral mucosa expressed newly...oral IL-12 gene therapy with another...lengths of time. "Oral mucosa may be one of...tissues for cancer gene therapy by means of particle...
- Gene Gun Therapy Via Oral Mucosa Generates System-Wide Tumor Inhibition.(Brief...
- Newspaper article from: Cancer Weekly December 18, 2001 700+ words
...following cancer gene therapy, researchers...suggested the oral mucosa expressed newly...oral IL-12 gene therapy with another...lengths of time. "Oral mucosa may be one of...tissues for cancer gene therapy by means of particle...
- Human papillomavirus is commonly found in oral mucosa.
- Newspaper article from: Cancer Gene Therapy Week March 15, 2004 700+ words
...but is also found in normal oral mucosa, researchers report...carcinoma (OSCC) vs. normal oral mucosa, and to correlate the virologic...common event in the normal oral mucosa." Zhang and colleagues...article was prepared by Cancer Gene Therapy Week editors from staff ...
- Hepatitis C Replicates In Oral Mucosa.(Brief Article)
- Newspaper article from: Virus Weekly May 22, 2001 700+ words
...replication of the hepatitis C virus in the oral mucosa. They suspect the virus may play a...hepatitis c virus replicates in the oral mucosa." According to their EASL conference...suggests that HCV may replicate in the oral mucosa. "We collected oral mucosa biopsy...
- Hepatitis C Replicates In Oral Mucosa.
- Newspaper article from: Hepatitis Weekly May 21, 2001 700+ words
...replication of the hepatitis C virus in the oral mucosa. They suspect the virus may play a...hepatitis c virus replicates in the oral mucosa." According to their EASL conference...suggests that HCV may replicate in the oral mucosa. "We collected oral mucosa biopsy...
- Polyunsaturated fatty acids in human oral mucosa can be determined...
- Newspaper article from: Medical Devices & Surgical Technology Week October 3, 2004 700+ words
...fatty acids (PUFA) contents of human oral mucosa noninvasively using a reagent-free...the noninvasive measurement of human oral mucosa, we have used infrared spectroscopy...fluctuation of the alkene peak position of oral mucosa suggested that the contents of PUFAs...
- Oral mucosa defends against Candida albicans infection in humans.
- Newspaper article from: TB & Outbreaks Week April 13, 2004 700+ words
...NewsRx.com & NewsRx.net) -- Oral mucosa defends against Candida albicans infection...infections. We created engineered human oral mucosa (EHOM), put them in contact with...beta expression and production by human oral mucosa in response to Candida albicans infections...
- Nickel- and cobalt-based implants can induce DNA damage in oral mucosa cells.
- Newspaper article from: Health & Medicine Week February 16, 2004 700+ words
...appliances can induce DNA damage in oral mucosa cells, researchers say. According...evaluating the presence of metal ions in oral mucosa cells, their cytotoxicity, and their...appliances can induce DNA damage in oral mucosa cells." Faccioni and colleagues published...
