AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Phase II Clinical Trial Of MVA-HPV-IL2 Initiated.(Brief Article)
2001 DEC 19 - (NewsRx.com & NewsRx.net) -- Transgene (TRGNY) announced the initiation of a Phase II clinical trial of its immunotherapeutic MVA-HPV-IL2 product candidate for the treatment of cervical cancer.
The trial will be conducted in Mexico and will include up to 57 women with varying stages of HPV 16 cervical cancer, each of whose cancer either is resistant to radiotherapy or has recurred after radiotherapy.
The Phase II clinical trial will be conducted at two sites in Mexico (Monterrey and Mexico City) and will evaluate the efficacy of multiple subcutaneous injections. The trial will be performed according an optimized design divided into two stages. The first stage will involve an interim analysis performed once 22 evaluable patients have been reviewed at six months post-treatment. If at least five patients respond to treatment in the first stage, the study will recruit 35 additional patients for a second stage of product candidate evaluation.
"We believe that immunotherapy could be used to successfully treat cervical cancer by inducing an immune response against HPV 16, the virus responsible for cervical cancer," said Gilles Belanger, Transgene. "This is an important step forward in the development of our HPV program. After collecting very encouraging data from the Phase I clinical trial of this product candidate, we're excited about the possibility of addressing the large unmet medical need for patients suffering from cervical cancer."
Transgene's MVA-HPV-IL2 product candidate uses the MVA virus to express two HPV antigens found in HPV 16, the E6 and E7 proteins. The new generation MVA vector is a highly attenuated pox virus that combines the advantages of a strain ...
- National HPV & Cervical Cancer Campaign Announces New Patient Guidelines...
- Press release article from: PR Newswire January 7, 2002 700+ words
...Cancer Month, the National HPV & Cervical Cancer Campaign announced new...the causal link between HPV and cervical cancer and the importance of regular...clinicians. The National HPV & Cervical Cancer Campaign's recommendations...
- Nobel Prize to HPV Researcher Highlights Importance of Cervical Cancer...
- Newspaper article from: Cancer Vaccine Week October 20, 2008 700+ words
...human papillomavirus (HPV) and cervical cancer has spurred lifesaving...the causal role of the HPV virus in cervical cancer spurred research teams...high-risk types of HPV associated with cervical cancer. Cervical cancer is...
- Cervical cancer risk rises if women HPV also have herpes infection. (Digests).
- Magazine article from: Perspectives on Sexual and Reproductive Health London, S. March 1, 2003 700+ words
...likely than women without cervical cancer to have HPV-infected cervical cells...Almost all of the women with cervical cancer were HPV-positive (91-95...s role as a cofactor in HPV-induced cervical cancer. Herpes lesions may allow...
- New Data Show Cervarix(TM), GSK's HPV 16/18 Cervical Cancer Candidate Vaccine,...
- Press release article from: PR Newswire June 5, 2006 700+ words
...vaccinated with GSK's cervical cancer candidate vaccine...response against HPV 16 and HPV 18...risk of developing cervical cancer due to infection by cancer-causing HPV types. These results...against oncogenic HPV infection to protect them against cervical ...
- Cervical cancer risk rises if women with HPV also have herpes infection....
- Magazine article from: International Family Planning Perspectives London, S. June 1, 2003 700+ words
...than women without cervical cancer to have HPV-infected cervical...conjunction with HPV infection to modestly...risk of invasive cervical cancer," the investigators...HP V-induced cervical cancer. Herpes lesions may allow HPV easier access to...
- STUDY SHOWS HPV TESTING SIGNIFICANTLY CUTS DEATHS FROM CERVICAL CANCER.
- News wire article from: AsiaPulse News April 2, 2009 700+ words
...international experts in cervical-cancer prevention should now adapt HPV testing for widespread...and deaths from cervical cancer," QIAGEN's hc2 HPV testing platform...increase access to HPV testing and cervical cancer prevention technologies...
- Digene HPV Test, Education and Early Detection Recommended As Effective Methods...
- Press release article from: PR Newswire February 11, 1999 700+ words
...Global Solutions to Cervical Cancer Detection and Elimination Revealed at HPV Summit - CHAMONIX...elimination of cervical cancer is within sight. The HPV Summit 1999 has...the benefits of HPV DNA testing in cervical cancer screening programs...
- New Local TV Ad Campaign To Educate Memphis Women About Cervical Cancer...
- Press release article from: PR Newswire February 9, 2009 700+ words
...are such big believers in cervical cancer prevention and HPV testing that they all appear...about the link between HPV and cervical cancer when I was diagnosed with...thehpvtest.com/. About HPV and cervical cancer: The American Cancer Society...