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Neonatal Vaccine Produces Antibody Response.(Brief Article)
2001 DEC 19 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in the United States have found an HIV vaccine candidate that may protect newborn infants from vertical transmission of the virus.
In a multicenter study, Dr. Elizabeth J. McFarland, University of Colorado in Denver, and colleagues at institutions in the U.S. and Puerto Rico and at Chiron Corporation in San Francisco evaluated the efficacy of a modified gp120-based vaccine. This vaccine triggered the emergence of HIV specific antibodies in neonates, they said.
The researchers compared the effects of a recombinant gp120 vaccine with Chiron's proprietary MF59 adjuvant at a number of dose levels and schedules. After 24 weeks, almost 90% of the infants studied demonstrated gp120-specific antibody response, according to their report.
An accelerated vaccine schedule enhanced the speed of HIV specific antibody development. More than 60% of the neonates on the accelerated schedule showed anti-gp120 antibody activity "distinct from transplacental maternal antibody" after 12 weeks, McFarland and coworkers reported.
Infants on the more-intensive schedule had an average antibody titer of ...
- Neonatal Vaccine Produces Antibody Response.
- Newspaper article from: Biotech Week December 19, 2001 700+ words
...HIV-1 transmission," McFarland and coauthors concluded...this report is Elizabeth J. McFarland, Dept. of Pediatrics...USA. E-mail: Betsy.mcfarland@uchsc.edu. A search...recombinant gp120-based vaccine produces HIV specific antibody responses...
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- Newspaper article from: Cancer Weekly June 5, 2001 700+ words
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- Newspaper article from: Immunotherapy Weekly June 6, 2001 700+ words
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