AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Antigen Fusion With Interferon-(gamma) Augments Efficacy.(Brief Article)
2001 DEC 19 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - A fusion protein made up of HIV gp120 and interferon-(gamma) holds promise as a candidate HIV vaccine, according to researchers in the United Kingdom.
"Cytokines, including interferon (IFN)-(gamma), can be effective immunologic adjuvants but often lack the potency of other, more reactogenic compounds," explained Adele L. McCormick and colleagues at the University of Sheffield Medical School in Sheffield.
McCormick and coauthors found that fusing IFN-(gamma) with gp120 strongly enhanced its immunogenecity.
The researchers created a number of chimeric proteins with amino acid linkers of different lengths. A 34-amino acid linker produced the best results, they said.
This fusion protein produced more potent gp120-specific antibody responses than vaccines containing mixed but not fused gp120 and IFN-(gamma). Immunoglobulin G2a (IgG2a) antibodies were especially active, study data showed.
The vaccine studied also augmented endogenous IFN-(gamma) production while stimulating T-cell proliferation ...
- Harvard Medical School Researchers use FLEX(TM) Pre-Clinical Imaging System to...
- Press release article from: Business Wire October 27, 2005 700+ words
...researchers from the Harvard Medical School working to develop new...system manufactured by Gamma Medica-Ideas. The...Hospital and Harvard Medical School in Boston. Dr. Ralph...cmir.org/. About Gamma Medica-Ideas Gamma...
- Harvard scientists pioneer new approach to cancer treatment. (Collaborative...
- Press release article from: PR Newswire May 20, 1988 700+ words
...Institute, Harvard Medical School, and the Argonne National...more powerful than the gamma radiation more commonly...tumors are treated with gamma radiation applied externally...penetrating nature of gamma radiation, healthy...investigators from the Harvard Medical School ...
- Philanthropist Paul F. Glenn Launches Labs For Aging Research At Harvard...
- News wire article from: AScribe Health News Service March 11, 2005 700+ words
...5 million to Harvard Medical School over five years to launch...Research at Harvard Medical School. "We are proud to...to be held at Harvard Medical School. "We structured this...human cells to survive gamma radiation, compared...
- Harvard Medical School Professor Announces a Safe and Natural Alternative to...
- Press release article from: PR Newswire November 1, 2004 700+ words
...Professor of Medicine at Harvard Medical School and Brigham and Women's Hospital...immune blood cell called the gamma-delta T cell. "We know from other studies that these gamma-delta T cells in the blood...anti-tumor activity. These gamma-delta T cells secrete interferon...
- Research on hepatitis C virus risk factors described by scientists at Medical...
- Newspaper article from: Hepatitis Weekly January 12, 2009 700+ words
...vitro interferon (IFN)-gamma production by T cells in response...injection episodes of 8760. IFN-gamma production in response to...Thurairajah and colleagues, Medical School. The researchers concluded...Research Group, Peninsula Medical School, Universities of Plymouth...
- Researchers from Medical School detail new studies and findings in the area of...
- Newspaper article from: Hepatitis Weekly October 19, 2009 700+ words
...proliferator-activated receptor-gamma. In mice genetically predisposed to...wrote C.Z. Larter and colleagues, Medical School. The researchers concluded: "The...Hospital, Liver Research Group, ANU Medical School, Garran, Australian Capital Territory...
- Researchers from Medical School, Department of Nuclear Medicine detail findings...
- Newspaper article from: Blood Weekly September 18, 2008 700+ words
...treadmill exercise was traced using a gamma-camera. Regional SMBF in absolute...wrote M. Seto and colleagues, Medical School, Department of Nuclear Medicine (see...information, contact M. Seto, Saitama Medical School Hospital, Dept. of Nuclear Medicine...
- Elekta to Deliver Leksell Gamma Knife(R) Perfexion(TM) to University of...
- Press release article from: Business Wire September 6, 2006 700+ words
...successfully treated with Leksell Gamma Knife Perfexion in mid July...market clearance for Leksell Gamma Knife Perfexion, allowing...personified. U.Va. was the tenth medical school established in the United States...include among others Leksell Gamma Knife(R) for non-invasive...
Source: HighBeam Research, Antigen Fusion With Interferon-(gamma) Augments Efficacy.(Brief...