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HIV Specific T Cells May Not Be Crucial For Early Protection.(Brief Article)
2001 DEC 12 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in the United States and Europe say that immune protection against acute HIV infection does not seem to be exclusively mediated by HIV specific T cells.
"Human immunodeficiency virus (HIV) specific T-cell responses are thought to play a key role in viral load decline during primary infection and in determining the subsequent viral load set point," explained Michael R. Betts and colleagues at the University of Texas Southwestern Medical Center in Dallas, the Vaccine and Gene Therapy Institute at Oregon Health Sciences University in Portland, and the Swiss Federal Institute of Technology in Zurich, Switzerland.
However, Betts and coworkers found that high HIV specific T cell counts did not guarantee viral suppression and in some cases seemed to have a deleterious effect on viral load.
The researchers examined HIV specific T-cell activity in 23 untreated HIV patients, testing CD4[superscript]+ and CD8[superscript]+ T-cell responses to every protein produced by the viral genome. All patients demonstrated HIV specific CD8 cell responses, and most (21 of 23) displayed an HIV specific CD4 cell response, they said.
Surprisingly, there was no correlation between the total CD4 cell response and HIV RNA levels, according to the report. The activity of CD4 cells targeting the HIV Gag protein was also not linked to viral load, and ...
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- HIV Specific T Cells May Not Be Crucial For Early Protection.(Brief Article)
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