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CpG Oligonucleotides Generate Antitumor Response In Rodents.(Brief Article)
2001 DEC 12 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Scientists have determined oligodeoxynucleotides containing CpG motifs (CpG-ODNs) can act as a tumor vaccine, preventing the formation of new tumors in rats cured of previously established glioma.
CpG-ODNs cause tumor rejection on two fronts, taking advantage of both innate immunity and specific immune response, based on evidence gathered by G. Auf and associates working for the French research consortium INSERM. Several investigations are presently underway in order to establish the possibility of using these CpG-ODNS as tumor vaccines.
Auf and INSERM colleagues used several types of rodents, including normal and macrophage depleted Fisher rats, and nude and SCID mice to perform their analyses of CpG-ODNs and immune system response.
Intermittent administration of CpG-ODNs to rats with normal macrophage levels up to 19 days after they were given subcutaneous inoculations of 9 L glioma cells resulted in significant reductions in tumor volume. In contrast, tumors continued to grow in control rats treated with normal saline. The effect of CpG-ODN therapy on tumor inhibition was seen in over a third of the treated rats, Auf and coworkers reported (Implication of macrophages in tumor rejection induced by CpG-oligodeoxynucleotides without antigen, Clinical Cancer Research, November 2001;7(11):3540-3543).
Tumor-specific long-term protective immunity was also evident, as cured ...
- RANTES, CpG ODNs effective as mucosal adjuvants.(chemokine RANTES;...
- Newspaper article from: AIDS Weekly March 17, 2003 700+ words
...and colleagues. The chemokine RANTES and CpG oligodeoxynucleotides (ODN) strongly improved...SIV) vaccine and either CT, RANTES, or CpG ODN. The treated animals were then challenged...to the report. Like CT, both RANTES and CpG ODN augmented SIV Env-specific antibody...
- RANTES, CpG ODNs effective as mucosal adjuvants.
- Newspaper article from: AIDS Vaccine Week March 17, 2003 700+ words
...and colleagues. The chemokine RANTES and CpG oligodeoxynucleotides (ODN) strongly improved...SIV) vaccine and either CT, RANTES, or CpG ODN. The treated animals were then challenged...to the report. Like CT, both RANTES and CpG ODN augmented SIV Env-specific antibody...
- 2'-O-methyl- groups stabilize the binding of phosphorothioate antisense ODNs.
- Newspaper article from: Drug Week June 25, 2004 700+ words
...the binding of phosphorothioate antisense ODNs. According to recent research from the...States, "antisense oligodeoxynucleotides (ODNs) have biological activity in treating...antisense effects of two types of 20mer ODNs, phosphorothioate-modified ODNs (S...
- AS-ODNs transferred to HCECs in vitro via ultrasound and microbubbles.
- Newspaper article from: Gene Therapy Weekly January 23, 2003 700+ words
...microbubbles. "Since antisense oligodeoxynucleotides (AS-ODNs) have been recognized as a new generation of putative therapeutic...we established a delivery technique that could transfect AS-ODNs, which are designed for endothelin type B receptor (ETB...
- AS-ODNs to nuclear enzyme ameliorate disease in IL-10-deficient mice.
- Newspaper article from: Gene Therapy Weekly January 23, 2003 700+ words
2003 JAN 23 - (NewsRx.com & NewsRx.net) -- According to a study from Canada, "Poly(ADP-ribose) polymerase-2 (PARP-2) is a newly described member of the PARP family of nuclear enzymes. Previous studies have shown pharmacological inhibition of PARP activity to have a beneficial role in
- Systemic administration of AS-ODNs used to create Apo E-deficient mice.
- Newspaper article from: Gene Therapy Weekly January 23, 2003 700+ words
2003 JAN 23 - (NewsRx.com & NewsRx.net) -- "Atherosclerotic cardiovascular disease results from complex interactions among multiple genetic and environmental factors. Thus, it is important to elucidate the influence of each factor on cholesterol metabolism. For this purpose,
- CpG ODN properties might be useful in developing immunotherapy adjuvants.
- Newspaper article from: Immunotherapy Weekly January 22, 2003 700+ words
...responses. "CpG oligodeoxynucleotides (CpG ODNs) are known to induce type 1 T-helper...have previously demonstrated that CpG ODNs administered during sensitization...Recent in vivo data suggest that CpG ODNs might also reverse established pulmonary...
- CpG oligodeoxynucleotides activate HIV replication in latently infected T cells.
- Newspaper article from: Blood Weekly July 29, 2004 700+ words
...cells. "CpG oligodeoxynucleotides (CpG ODNs) stimulate immune cells via the Toll...we have investigated the effects of CpG ODNs on latent human immunodeficiency virus...infected T cell line ACH-2 with CpG ODNs 2006 or 2040 stimulated HIV replication...
