AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Vaccine Progresses to Phase II Human Trails.(Brief Article)
2001 DEC 5 - (NewsRx.com & NewsRx.net) -- Antex Biologics, Inc. (ANX) has completed laboratory analyses of its Phase 1B clinical trial of Helivax, the Company's oral vaccine intended to prevent and treat gastrointestinal infections and disease caused by Helicobacter pylori.
The primary objective of this second human trial was to evaluate the effect of mucosal adjuvant doses with several different vaccine formulations. As reported earlier, all formulations and dosages were found to be safe and did not cause any adverse clinical events, and the vaccine stimulated serum, mucosal and salivary antibodies against H. pylori.
The laboratory analysis of the cellular immune response and fecal antibody production has been completed. As anticipated based on the earlier reported results, the vaccinated volunteers were positive for immune cell proliferation, cytokine production, and secretory IgA antibodies. These efficacy results provide the basis for proceeding to a Phase II clinical trial, which will be conducted in early 2002.
"The results of this Phase IB trial ...
- AXCAN ANNOUNCES FINAL RESULTS FOR ITS HELICIDE PHASE III NORTH AMERICAN TRIAL:...
- Press release article from: PR Newswire October 16, 2000 700+ words
...announced today final results of the Phase III North American pivotal clinical...125 mg), for the eradication of Helicobacter pylori. Results were presented at the...gastric and duodenal ulcers. The Phase III study, initiated in September...
- Axcan Announces Final Results For Its HELICIDE(TM) Phase III North American...
- Press release article from: PR Newswire October 16, 2000 700+ words
...announced today final results of the Phase III North American pivotal clinical...125 mg), for the eradication of Helicobacter pylori. Results were presented at the...gastric and duodenal ulcers. The Phase III study, initiated in September...
- NOVAVAX RECEIVES PERMISSION TO BEGIN PHASE I MULTIPLE DOSE TESTING OF...
- Press release article from: PR Newswire February 21, 1996 700+ words
...infected patients. Helicobacter pylori is a bacterial infection...designed to eradicate Helicobacter pylori infection in humans...in a single dose Phase I toxicity study...with asymptomatic Helicobacter pylori infection will receive...
- Axcan Receives Canadian Approval for Helicide, a Single Capsule Triple Therapy...
- Press release article from: PR Newswire March 17, 2003 700+ words
...pylori eradication. Helicobacter pylori infects half of the...Once a diagnosis of Helicobacter pylori infection has been...the eradication of Helicobacter pylori reduces the rate...The Phase III North American...
- New helicobacter pylori findings from Novartis published.(Clinical report)
- Newspaper article from: Cancer Vaccine Week October 27, 2008 700+ words
...report (see also Helicobacter pylori). "We sought...single-blind Phase I study randomized...intramuscular Helicobacter pylori vaccine in noninfected...volunteers: A Phase I study. Gastroenterology...Italy, Siena, Helicobacter pylori, Biotechnology...
- Research from Sejong University yields new data on helicobacter pylori.
- Newspaper article from: Gastroenterology Week June 8, 2009 700+ words
...regulation of Helicobacter pylori proteins by Fur...to the growth phase, we compared...report (see also Helicobacter pylori). "Clustering...that the growth-phase-dependent protein...Alteration of growth-phase-dependent protein...fur mutation in Helicobacter ...
- Antex Biologics Receives Patent for Helicobacter Pylori Vaccine.
- Press release article from: PR Newswire April 26, 2000 700+ words
...successfully completed a Phase I clinical trial. The clinical...Ellingsworth. Results from the Phase I clinical trial were presented...this patent are directed to Helicobacter pylori vaccine, methods for producing...enhances the expression of Helicobacter pylori antigens or virulence ...
- Amarillo Biosciences, Inc. Receives SBIR Grant to Develop Vaccine For...
- Press release article from: PR Newswire October 16, 2001 700+ words
...vaccine to combat Helicobacter pylori, a major cause of...Laramie, Wyoming. Helicobacter pylori (H. pylori) is...gnotobiotic piglet model of Helicobacter pylori is very encouraging...vaccine. If the Phase I work goes as expected...
- Effect of Helicobacter pylori eradication on treatment of gastro-oesophageal...
- Magazine article from: Gut Wu, J.C.Y. Chan, F.K.L. Ching, J.Y.L. Leung, W.-K. Hui, Y. Leong, R. Chung, S.C.S. Sung, J.J.Y. February 1, 2004 700+ words
...179 Background: The role of Helicobacter pylori eradication in the management...oesophagitis at the initial treatment phase, or relapse of symptoms and...therapy. (1 2) The effects of Helicobacter pylori infection in patients with GORD...
- Characteristics of Helicobacter pylori Motility in vivo and in vitro.
- Magazine article from: Gut Yamamoto, T. Taneike, I. Zhang, H.M. Goshi, S. October 1, 2001 700+ words
[1/06] [*] Characteristics of Helicobacter pylori Motility in vivo and in vitro Helicobacter pylori is a spiral-shaped bacterium with multiple...layer was examined under an inverted, phase-contrast microscope with a microwarm...
Source: HighBeam Research, Vaccine Progresses to Phase II Human Trails.(Brief Article)