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Cyclacel Receives Patent On Drug Target Of Cancer Cell Cycle.(Brief Article)
2001 NOV 21 - (NewsRx.com & NewsRx.net) -- Cyclacel, Ltd., has been granted United States Patent 6,242,201 covering the cancer drug target PCNA (proliferating cell nuclear antigen).
Cyclacel's CYC102 program is seeking to prevent cancer cell proliferation through drugs acting on PCNA. The CYC102 studies are based on the understanding that inhibition of PCNA prevents DNA replication, a prerequisite to cancer cell division. Cyclacel is working on this target because it is associated with the body's own tumour suppression systems, such as the p21 protein that prevents cancer cell division by inhibiting PCNA.
Cyclacel's new U.S. patent specifically covers both substances that mimic the structure and activity of the p21 tumor suppressor protein and screening assays for such compounds. An equivalent patent is already granted in Europe as European Patent 0789711. A further European Patent 0871655 has been granted to Cyclacel claiming mimetics and assays relating to PCNA's interaction with Fen1, another protein with similar function to p21.
The inventors on these patents include Professor Sir David Lane, Cyclacel's chief scientific officer, and Professor David Glover, chief scientist of Cyclacel's Polgen target discovery division.
Glover said, "It is gratifying to see that our early academic insights on this key cancer target are validated by recent ...
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Source: HighBeam Research, Cyclacel Receives Patent On Drug Target Of Cancer Cell Cycle.(Brief...