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Cellular Factors Expand Grass Allergen Vaccine Effectiveness.(Brief Article)
2001 NOV 21 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Vectors encoded with the genes for two cytokines will increase allergen immunotherapy effectiveness.
The two cytokines, interferon (IFN)-gamma and interleukin (IL)-12, enhanced the benefits of grass allergen vaccines when administered alone or in combination in encoded plasmids (p), researchers at the University of South Florida reported in Journal of Allergy and Clinical Immunology.
M. Kumar and associates used a murine model of Kentucky blue grass allergy to explore the added benefits of plasmid-based cytokine inoculation.
"Groups of naive B6D2F1 mice were vaccinated subcutaneously with KBG allergens and administered intramuscularly with pIFN-gamma, pIL-12, pIFN-gamma plus pIL-12, or a vector control," described Kumar and coworkers.
Vaccines containing KBG allergens were then administered to the mice in order to sensitize them. Finally, the mice were challenged with grass allergens in order to assess inflammatory response, specific immune response, and airway response.
Compared with control mice, those vaccinated with either of the encoded plasmids formed higher levels of allergen-specific immunoglobulin (Ig)G2a and lower levels of IgE, which are associated with hypersensitivity reactions, and serum values for both immunoglobulins were altered even more in mice treated with a ...
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Source: HighBeam Research, Cellular Factors Expand Grass Allergen Vaccine Effectiveness.(Brief...