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Metabolite Betaine Improves Liver Status In Nonalcoholic Steatohepatitis.(Brief Article)
2001 NOV 15 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Betaine, a byproduct of choline metabolism, improves liver function and pathology in patients with nonalcoholic steatohepatitis (NASH), or fatty liver.
This disease, mostly affecting women and especially the obese, is characterized by excessive fat deposits within the liver cells. Based on a preliminary study, Mayo Clinic researchers in Rochester, Minnesota, say betaine (Cystadane) improves liver status in some people with NASH.
According to M.F. Abdelmalek and colleagues, 10 patients with NASH were prescribed twice-daily oral doses of Cystadane for 12 months, with 7 of the patients completing the full length of the trial. Cystadane is usually used for treating patients with high levels of the amino acid homocysteine in the blood.
In three of the seven patients, serum levels of liver enzymes (aminotransferases) normalized, in another three patients enzyme levels fell by more than half, and levels stayed elevated in the remaining patient. Even in patients who did not complete the full 12 month regimen, serum levels of liver enzymes improved.
By the trial's end, liver biopsies indicated improved status for fibrosis, ...
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