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Genetic Profiling May Play Greater Role In Identifying At-Risk Women.(Brief Article)
2001 NOV 15 - (NewsRx.com & NewsRx.net) -- A team of Cambridge University scientists have identified variants in six genes that may help to identify women at risk from breast cancer. They reported the findings at ECCO 11 - the European Cancer Conference in Lisbon, Portugal.
A strong family history, involving dominant genes, is already well established as a cause of breast cancer. Mutations in the so-called BRCA1 and 2 genes are estimated to account for about 15-20% of familial breast cancer.
But the Cambridge research may lead to the development of further tests to identify women who are at risk from other genetic mutations. Professor Bruce Ponder, of the Cancer Research Campaign Department of Oncology at the university, said, "The number and type of genes that account for the remainder of familial breast cancer is not clear. It is, however, plausible, that at least some of this genetic predisposition is attributable to the effects of multiple, common, but individually weak genes."
Identifying such genes could help scientists to create "genotype profiles" to determine the risk of individual women at risk from the disease. These could be used in presymptomatic screening, diagnosis, and treatment ...
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Source: HighBeam Research, Genetic Profiling May Play Greater Role In Identifying At-Risk...