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Erlotinib For Lung, Breast Cancers Starts Trials.(Brief Article)
2001 NOV 15 - (NewsRx.com & NewsRx.net) -- Studies testing the potential of leading drug candidate Tarceva (erlotinib) in treating two of the most common cancers, lung and breast, opened in October (2001) at a number of centers around the world.
Tarceva is a small molecule, antiepidermal growth factor receptor (EGFR) drug candidate that has demonstrated encouraging anticancer activity in single agent, open label Phase II studies in NSCLC, head and neck cancer and ovarian cancer.
The TALENT (Tarceva Lung Cancer Investigation) trial will measure whether Tarceva improves the duration of survival for patients with non-small cell lung cancer (NSCLC). The multicenter, 1000 patient study is one of two randomized, controlled Phase III trials in NSCLC that will assess the value of adding Tarceva to two of the most commonly used front-line combination chemotherapy regimens for NSCLC (gemcitabine/cisplatin and carboplatin/paclitaxel). A previous open label Phase II study with single agent Tarceva in lung cancer has shown that the drug has encouraging antitumor activity - with 48% of 57 patients showing either a ...
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