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Coagulation-Related Mutations May Be Risk Factor.(Brief Article)
2001 NOV 15 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Polymorphisms in genes coding for key anticoagulant proteins may heighten the risk of miscarriage, researchers in Italy warn.
"Late fetal loss can be associated with placental insufficiency and coagulation defects," explained Dr. Franca Franchi and colleagues at the Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre and Ospedale San Paulo, both affiliated with the University of Milan.
Women who suffered miscarriages were more likely than other women to carry mutations disrupting the protein C anticoagulant pathway, Franchi and coworkers reported.
"Thrombomodulin (TM) and the endothelial protein C receptor (EPCR) are glycoprotein receptors expressed mainly on the endothelial surface of blood vessels and also in the placenta," they said. The researchers compared the rate of polymorphisms affecting these proteins in 95 women who miscarried after 20 weeks gestation and in 236 mothers with no history of complications.
A total of 7 mutations were found in 95 patients suffering fetal loss, 5 in the thrombomodulin gene and 2 in the gene coding for endothelial protein C receptor. By contrast, only 4 such mutations were found in the 236-member control group, study data showed.
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Source: HighBeam Research, Coagulation-Related Mutations May Be Risk Factor.(Brief Article)