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2001 NOV 15 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - The novel tumor suppressor maspin, an angiogenesis inhibitor, prevents cancer growth and spread in a murine model of mammary cancer.
Researchers believe these same effects might be seen in human breast cancers, according to a report in Cancer Research.
H.Y. Shi and colleagues at Baylor College of Medicine in Houston, Texas, explained that in vivo and in vitro analyses of maspin, a serine protease inhibitor, have revealed it can inhibit angiogenesis, tumor cell migration, and tumor progression.
"To additionally prove that maspin is directly involved in the suppression of tumor growth and metastasis, we tested maspin in a new syngeneic mammary tumor model, TM40D," Shi and coworkers said.
In the latest of their studies, Shi's team transplanted TM40D cells directly into murine mammary glands in order to follow invasion and metastatic activity. According to the group, tumor cell dissemination was readily apparent after transplantation and before treatment (Blocking tumor growth, invasion, and metastasis by maspin in a syngeneic breast cancer model, Cancer Res, 2001;61(18):6945-6951).
"However, both primary tumor growth and ...