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Complementary DNAs Detected In Breast Tumors Possess Vaccine Potential.(Brief Article)
2001 NOV 14 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Researchers at a major cancer center in Buffalo, New York, have identified a transcription factor that has potential for developing a breast cancer vaccine.
Investigators at the Roswell Park Cancer Institute in New York report prostate epithelium-derived Ets transcription factor (PDEF) can be identified in breast cancer tumors and might be used as a vaccine antigen to prevent breast cancer.
"There is a need to identify novel breast tumor-associated molecules with a potential as diagnostic/prognostic markers of breast cancer as well as targets of vaccine and drug discovery against this cancer," A. Ghardersohi and colleagues noted in Clinical Cancer Research.
With advanced digital evaluation devices and reverse transcription-polymerase chain reaction (RT-PCR), Ghardersohi and team were able to detect PDEF as well as five other complementary DNAs (cDNAs) in human breast tissue and breast tumors that could only be detected at minute levels in other normal human tissues.
Although PDEF was detected in 14 of 20 human breast cancer tissues, advanced analyses showed its expression was limited in normal breast tissues (Prostate epithelium-derived Ets transcription factor mRNA is overexpressed in human breast tumors and ...
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Source: HighBeam Research, Complementary DNAs Detected In Breast Tumors Possess Vaccine...