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Botanical-Based Therapy Has Effect Similar To Low-Dose Chemo.
2001 NOV 14 - (NewsRx.com & NewsRx.net) -- The combination botanical therapy called PC-SPES has been found to be effective at affecting measures that indicate prostate cancer activity, according to Sophie Chen, PhD, a leading expert in drug development.
"PC-SPES means hope for prostate cancer," said Dr. Chen, associate research professor at New York Medical College in Valhalla and the director of NovaSpes Research Laboratory in Hawthorne, New York. "In fact, PC-SPES is delivering more than hope to prostate cancer patients. The pharmacological action of the mixture involves multiple molecular pathways and can be translated into three factors: (1) anticancer activity, (2) phytoestrogenic activity, (3) immune modulation activity. These activities are demonstrated in the in vitro, animal model and several clinical studies."
Dr. Chen spoke at the recent 20th Annual Science Reporters Conference of the American Medical Association in San Francisco. The immunotherapy drug is composed of botanical compounds and extracts from seven Chinese herbs (Dendranthema morifolium; Ganoderma lucidium; Glycyrrhiza uraensis; Isatis indigotica; Panax pseudo-ginseng; Rabdosia rubescens; Scutellaria baicalensis) and one American herb (Serenoa repens). In the laboratory, each compound has demonstrated the ability to directly kill cancer cells or stimulate the body's immune system to help fight cancer. The synergy of all of the herbs together makes the combination a powerful anticancer treatment, according to Dr. Chen.
The anticancer activity is similar to the mechanism of low doses of conventional chemotherapy. PC-SPES suppresses cancer-causing genes such as Bcl-2 while boosting the immune system, thus promoting the body's natural cancer suppressor genes, p53 and Bax. "In most cancer patients, some natural cancer suppressor genes, like p53 and Bax, are missing or the genes have mutated," said Dr. Chen. The suppression of the cancer-promoting genes BCL-2 is similar to conventional chemotherapy, but the building up of the immune system contrasts with the chemotherapeutic ...
- Evaluation of PC-SPES in Prostate Cancer Patients.(Clinical report)
- Newspaper article from: Clinical Oncology Alert January 1, 2001 700+ words
Evaluation of PC-SPES in Prostate Cancer Patients ABSTRACT...Phase II study of the herbal supplement PC-SPES was performed with 33 androgen-dependent...Additional measures of response to PC-SPES, including bone scan improvement and...
- PC-SPES Lowers Prostate Specific Antigen Levels but Induces Estrogenic Effects.
- Newspaper article from: Cancer Weekly November 14, 2000 700+ words
...analysis, the herbal therapeutic PC-SPES diminishes evidence of prostate cancer...generating estrogen-type side effects. PC-SPES is a combination of eight Chinese...in capsule form. An analysis of PC-SPES was carried out in New York at the...
- PC-SPES for Prostate Cancer.(herbal preparation for prostate cancer treatment)
- Magazine article from: Townsend Letter for Doctors and Patients April 1, 2001 700+ words
PC-SPES is an herbal preparation that has became...and from the Latin word for "hope." PC-SPES contains eight herbs: Dendranthema morifolium...Cancer Center in New York, suggests that PC-SPES does have beneficial effects in men with...
- Tainted supplements. (Caution).(PC-SPES, SPES supplements tainted with warfarin...
- Magazine article from: Environmental Nutrition April 1, 2002 700+ words
...of the herbal supplements known as PC-SPES and SPES, stop their use immediately. PC-SPES (spes means "hope" in Latin...you still have a supply of SPES or PC-SPES at home, return it in its original...
- First clinical evidence of PC SPES efficacy in prostate cancer.
- Magazine article from: Nutraceuticals International June 1, 1999 700+ words
...containing eight herbs, sold in the USA as PC SPES by Botaniclab and other companies...participants received nine capsules daily of PC SPES, and the majority of these men are...supplement. The eight herbs that comprise PC SPES are chrysanthemum (Dendranthema morifolium...
- PC-SPES analysis confirms presence of synthetic compounds. (Industry News).
- Magazine article from: Nutraceuticals World May 1, 2002 700+ words
...drug diethylstilbestrol (DES) in PC-SPES, the herbal supplement used by prostate...inflammatory drug indomethacin in samples of PC-SPES manufactured from 1996 through 2001...unique chemical constituent found in PC-SPES. Researchers also turned their attention...
- Herbal cancer remedy is chock full of drugs. (Biomedicine).(study finds PC-SPES...
- Magazine article from: Science News September 21, 2002 700+ words
...1996 and 2001. The product, called PC-SPES, has since been recalled by its...when seriously ill patients taking PC-SPES began to fare better than expected...that the known herbal ingredients in PC-SPES all failed individually to have much...
- NCCAM ends PC-SPES studies. (Top of the News).(National Center for...
- Magazine article from: Nutraceuticals World July 1, 2002 700+ words
...studies that were to be conducted on the herbal supplement PC-SPES, which was recalled earlier this year. As a result of...standards on products used in research it funds in light of PC-SPES contamination problems.