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Botanical-Based Therapy Has Effect Similar To Low-Dose Chemo.
2001 NOV 14 - (NewsRx.com & NewsRx.net) -- The combination botanical therapy called PC-SPES has been found to be effective at affecting measures that indicate prostate cancer activity, according to Sophie Chen, PhD, a leading expert in drug development.
"PC-SPES means hope for prostate cancer," said Dr. Chen, associate research professor at New York Medical College in Valhalla and the director of NovaSpes Research Laboratory in Hawthorne, New York. "In fact, PC-SPES is delivering more than hope to prostate cancer patients. The pharmacological action of the mixture involves multiple molecular pathways and can be translated into three factors: (1) anticancer activity, (2) phytoestrogenic activity, (3) immune modulation activity. These activities are demonstrated in the in vitro, animal model and several clinical studies."
Dr. Chen spoke at the recent 20th Annual Science Reporters Conference of the American Medical Association in San Francisco. The immunotherapy drug is composed of botanical compounds and extracts from seven Chinese herbs (Dendranthema morifolium; Ganoderma lucidium; Glycyrrhiza uraensis; Isatis indigotica; Panax pseudo-ginseng; Rabdosia rubescens; Scutellaria baicalensis) and one American herb (Serenoa repens). In the laboratory, each compound has demonstrated the ability to directly kill cancer cells or stimulate the body's immune system to help fight cancer. The synergy of all of the herbs together makes the combination a powerful anticancer treatment, according to Dr. Chen.
The anticancer activity is similar to the mechanism of low doses of conventional chemotherapy. PC-SPES suppresses cancer-causing genes such as Bcl-2 while boosting the immune system, thus promoting the body's natural cancer suppressor genes, p53 and Bax. "In most cancer patients, some natural cancer suppressor genes, like p53 and Bax, are missing or the genes have mutated," said Dr. Chen. The suppression of the cancer-promoting genes BCL-2 is similar to conventional chemotherapy, but the building up of the immune system contrasts with the chemotherapeutic ...
- Evaluation of PC-SPES in Prostate Cancer Patients.
- Newspaper article from: Clinical Oncology Alert January 1, 2001 700+ words
...II study of the herbal supplement PC-SPES was performed with 33 androgen...Additional measures of response to PC-SPES, including bone scan improvement...and allergic reactions (n = 3). PC-SPES has activity in the treatment of...
- PC-SPES for Prostate Cancer.(herbal preparation for prostate cancer treatment)
- Magazine article from: Townsend Letter for Doctors and Patients April 1, 2001 700+ words
PC-SPES is an herbal preparation that has became...and from the Latin word for "hope." PC-SPES contains eight herbs: Dendranthema morifolium...Cancer Center in New York, suggests that PC-SPES does have beneficial effects in men with...
- Recall of PC SPES. (In The News).(herbal supplements from BotanicLab Inc.)
- Newspaper article from: Alternative Medicine Alert April 1, 2002 700+ words
...dietary supplement herbal products PC SPES and SPES because they contain undeclared...taken under medical supervision. PC SPES and SPES are marketed for prostate...manufacturer, has voluntarily recalled PC SPES and SPES nationwide. The California...
- Herbal prostate Tx had serious contaminants. (Demise of PC SPES).(treatment)
- Magazine article from: Family Practice News Walsh, Nancy December 1, 2002 700+ words
...data show that the herbal supplement PC SPES contained even more contamination...spectroscopy has shown that some lots of PC SPES marketed between 1996 and 2001 contained...Our serial lot analyses found that PC SPES lots manufactured from 1996 through...
- Tainted supplements. (Caution).(PC-SPES, SPES supplements tainted with warfarin...
- Magazine article from: Environmental Nutrition April 1, 2002 700+ words
...of the herbal supplements known as PC-SPES and SPES, stop their use immediately. PC-SPES (spes means "hope" in Latin...you still have a supply of SPES or PC-SPES at home, return it in its original...
- Adulterated herbal products recalled. (In the News).(PC SPES and SPES recalled...
- Newspaper article from: Alternative Therapies in Women's Health March 1, 2002 700+ words
...and stimulate the immune system, PC SPES and SPES, have been found to be adulterated...warfarin and alprazolam, respectively. PC SPES most commonly is used for prostate...products, voluntarily has recalled PC SPES and SPES nationwide. Consumers should...
- Medical Memo - PC-SPES: A cautionary tale.(prostate cancerhope (spes), Chinese...
- Newspaper article from: Harvard Men's Health Watch December 1, 2002 700+ words
...physicians and pharmacists clear it. But PC-SPES was the most aggressively promoted...prostate cancerhope (spes in Latin). PC-SPES is a combination of eight herbs that...The Lancet called for more study of PC-SPES. But at a cost of up to $486 a...
- Herbal cancer remedy is chock full of drugs. (Biomedicine).(study finds PC-SPES...
- Magazine article from: Science News September 21, 2002 700+ words
...1996 and 2001. The product, called PC-SPES, has since been recalled by its...when seriously ill patients taking PC-SPES began to fare better than expected...that the known herbal ingredients in PC-SPES all failed individually to have much...
- The Law Firm of Blumenthal & Markham Announces a Proposed Class Action...
- Press release article from: Business Wire February 6, 2007 700+ words
...Action Settlement regarding the unlawful distribution of "PC-Spes". This case, called Mittleholtz v. International Medical...your full name, address and signature. Mail it to: PC-SPES Litigation, Class Administrator, c/o Gilardi &...
- Reining in SPEs: New rules for special-purpose entities may result in bigger...
- Magazine article from: CFO, The Magazine for Senior Financial Executives Osterland, Andrew May 1, 2002 700+ words
...so-called special-purpose entities (SPEs) but guaranteed by Adelphia. Even the...both of which make extensive use of SPEs in their finance operations, have been...financial statements. "With all the focus on SPEs, we realized we should provide more details...
Source: HighBeam Research, Botanical-Based Therapy Has Effect Similar To Low-Dose Chemo.