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Drug May Prevent Wasting Often Seen In Victims Of Burns And Auto Wrecks.

Immunotherapy Weekly

| November 14, 2001 | COPYRIGHT 2001 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2001 NOV 14 - (NewsRx.com & NewsRx.net) -- A widely used blood pressure drug shows strong potential for slowing the metabolic overdrive that makes patients waste away after severe burns and other major injuries, researchers say.

The long-recognized phenomenon stems from the body's fight to heal itself. It ramps up metabolic functions and quickens heart rate but ultimately overshoots, eating away muscle and bone and weakening the patient.

Skin grafts can dampen this hypermetabolism in burn patients, but scientists have also tested drugs such as insulin and anabolic steroids. Some show benefit, but none has worked well enough for general use.

In a study in the October 25, 2001, issue of the New England Journal of Medicine, researchers at Shriners Hospital for Children in Galveston, Texas, tried propranolol on 13 children with bad burns and left 12 untreated to compare. The drug, one of a class known as beta blockers, checks the stimulating action of the hormone adrenaline and helps keep heart rates down in cardiac patients.

In the Texas experiment, the drug eased the children's heart rates an average of 20%. More significantly, the youngsters lost just 1% of muscle and bone mass over four weeks of ...

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