AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Genta's Decoy Program Suppresses Key Cancer Genes In Breast and Ovarian Cancer.(Decoy Aptamer)
2001 NOV 8 - (NewsRx.com & NewsRx.net) -- Genta Inc. has announced the publication of two scientific papers that show an important pipeline drug downregulated key cancer genes and exerted potent preclinical antitumor activity in breast and ovarian cancer. Using the Company's lead compound from its "Decoy Aptamer" program, the new papers derive from the laboratory of Dr. Yoon S. Cho-Chung from the U.S. National Cancer Institute. Genta holds an exclusive license to this technology.
"Decoy" technology involves using short DNA sequences to target proteins known as "transcription factors" that normally bind specific sequences in genomic DNA, thereby regulating downstream production of a protein. "Decoys" attach themselves to these factors, prevent their binding to DNA, and - depending upon whether the factor is a positive or negative regulator - can be used to selectively turn a gene on or off. The company believes that this technology can be used to affect production of proteins that are critically involved in cancer growth and metastasis.
In two new papers, decoys targeted the cyclic AMP response element binding protein (CRE-BP), which plays a ...
- CRE-decoy aptamer showed significant activity in hormone-resistant breast...
- Newspaper article from: Cancer Weekly December 31, 2002 700+ words
...s key pipeline products, the CRE-decoy aptamer. The results were presented at the...based medicine called the "CRE-decoy aptamer." This drug binds to and blocks the...examined the effects of Genta's CRE-decoy aptamer on more than 1000 human genes, using...
- CRE-decoy aptamer showed significant activity in hormone-resistant breast...
- Newspaper article from: Genomics & Genetics Weekly January 3, 2003 700+ words
...s key pipeline products, the CRE-decoy aptamer. The results were presented at the...based medicine called the "CRE-decoy aptamer." This drug binds to and blocks the...examined the effects of Genta's CRE-decoy aptamer on more than 1000 human genes, using...
- Broad Genomic and Anticancer Activity of Genta's CRE-Decoy Aptamer Presented at...
- Press release article from: PR Newswire November 26, 2002 700+ words
...s key pipeline products, the CRE-decoy aptamer. The results were presented at the...based medicine called the "CRE-decoy aptamer". This drug binds to and blocks the...examined the effects of Genta's CRE-decoy aptamer on more than 1,000 human genes...
- New Publications Show Genta's Decoy Program Suppresses Key Cancer Genes in...
- Press release article from: PR Newswire October 8, 2001 700+ words
...in breast and ovarian cancer. Using the...compound from its "Decoy Aptamer" program...of breast and ovarian cancer cells. These...for metastatic ovarian cancer." Abstracts...antisense and decoy aptamer technology...
- Ovarian cancer strikes one in 68 women: Now experts agree on a set of symptoms...
- Newspaper article from: Tulsa World (Tulsa, OK) August 2, 2007 700+ words
...estimated 15,000 Americans die of ovarian cancer, where malignant cells are found in...organs, the ovaries. For a long time, ovarian cancer was called the "silent killer" because...poor. Almost 70 percent of women with ovarian cancer are not diagnosed until the disease...
- Ovarian Cancer
- Encyclopedia entry from: Gale Encyclopedia of Medicine, 3rd ed. Rastegari, Esther; Frey, Rebecca January 1, 2006 700+ words
Ovarian Cancer Definition Ovarian cancer is cancer of the ovaries, the egg-releasing and hormone...located. Although it is a distinct disease, it is linked with ovarian cancer. This is because the ovarian and peritoneal cells have the...
- Ovarian Cancer; Facts to Know.
- Newspaper article from: NWHRC Health Center - Ovarian Cancer March 16, 2005 700+ words
* What is ovarian cancer? There are almost 40 different types of ovarian cancer. However, nine out of 10 ovarian cancer patients have a common epithelial tumor, which begins in the surface tissue of the ovary (epithelium). * What causes ovarian...
- Ovarian Cancer Does Have Early Warning Signs; Mayo Clinic and Olmsted Medical...
- News wire article from: AScribe Health News Service November 18, 2004 700+ words
...symptoms recorded in the medical records of ovarian cancer patients suggest ovarian cancer, long considered asymptomatic until late...urinary incontinence and abdominal pain. "Ovarian cancer is called 'the silent killer,'" says...
Source: HighBeam Research, Genta's Decoy Program Suppresses Key Cancer Genes In Breast and...