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Better Outcomes Seen In Children With Maternal Donors.(of stem cells)
2001 NOV 8 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Children who receive stem cells taken from their mothers are more likely to have a positive outcome than those who receive paternal grafts, researchers in Japan say.
"During the reproductive period, mothers and offspring exchange hematopoietic cells and develop a form of immunological tolerance bidirectionally," explained Dr. Tatsuo Ichinohe and colleagues at Kyoto University, Hiroshima Red Cross Hospital and Atomic Bomb Survivor's Hospital, Yamada Red Cross Hospital in Misono, and the Aichi Cancer Center Research Institute, Japan Society for Hematopoietic Cell Transplantation, and Nagoya Daini Red Cross Hospital in Nagoya.
Perhaps because of this immunological tolerance, children who received maternal grafts had improved chances for survival, Ichinohe and coauthors found.
The researchers performed a retrospective study comparing data from 46 pediatric stem cell recipients with maternal donors and 50 who were treated with paternal grafts. The children were treated between 1990 and 1998 according to their report.
Five years after transplantation, children who received stem cells from their mothers had an overall survival rate of 60%, study data showed. This rate was significantly higher than the 32% survival rate seen in children who received paternal stem cells. Parental donor type was the only variable with a significant impact on survival, the researchers noted.
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