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Very Early Pregnancy Test Might Not Always Be Accurate.
2001 NOV 8 - (NewsRx.com & NewsRx.net) -- Because of variations in when an early embryo may implant in a woman's body, performing pregnancy testing on the first day of the missed period may lead to a false-negative test result in some women, according to an article in the October 10 issue of the Journal of the American Medical Association (286:1759-1761).
Allen J. Wilcox, MD, PhD, of the National Institute of Environmental Health Sciences, Durham, North Carolina, and colleagues studied 221 women, 21 to 42 years of age, who were planning to conceive. The women kept track of their menstrual cycles and froze urine samples for later analysis. The authors used an extremely sensitive test to analyze the urine for human chorionic gonadotropin (hCG), a hormone that increases following implantation and indicates early pregnancy.
Of 136 women who conceived, implantation was estimated to have occurred by the first day of the missed period in 90%. For 10% of women who became pregnant, the hCG test obtained on the first day of the expected missed period was negative, suggesting that implantation occurred later. "The highest possible screening sensitivity for an hCG-based pregnancy test therefore is estimated to be 90% on the first day of the missed period," the authors wrote.
According to background information in the article, pregnancy cannot be determined before implantation of the blastocyst (early embryo). "The time of implantation has its own ...
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Source: HighBeam Research, Very Early Pregnancy Test Might Not Always Be Accurate.