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Sperm Antigen Might Be Good Contraception, Solve Reproductive Problems.
2001 OCT 24 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - The new discovery of a cDNA fragment that encodes for sperm antigen could some day be used for developing methods that enhance human reproductive medicine.
Ramasamy Santhanam and a colleague at the Medical College of Ohio discovered a new cDNA fragment that codes for sperm antigen called TSA-1 after using testis-specific cDNA to screen a portion of the human gene library. Recombinant TSA-1 could eventually be used in a contraceptive vaccine or for screening men with infertility, according to Santhanam and coworkers
"The computer-generated translated protein has a calculated molecular mass of 17.4 kDa and contains a potential N-glycosylation site at amino acids 122-124," described Santhanam and coauthors in the September 2001 edition of Molecular Reproduction and Development. Additional analysis showed that only testis tissues produce TSA-1.
When Santhanam's team produced a recombinant protein by subcloning TSA-1 with a pGEX-6P-3 vector, they found it could generate sperm-specific antibodies and might be of value for use in human contraceptives (Novel human testis-specific cDNA: Molecular cloning, expession and immunobiological effects of the ...
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Source: HighBeam Research, Sperm Antigen Might Be Good Contraception, Solve Reproductive...