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Canarypox-Based Vaccines Trigger (gamma) (delta) T-Cell Activity.
2001 OCT 24 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - HIV and other vaccines using canarypox vectors provoke enhanced (gamma) (delta) T-cell responses compared with other vaccines, researchers in Missouri report.
Shewangizaw Worku and colleagues at the St. Louis University Health Sciences Center and the St. Louis Department of Veterans Affairs Medical Center studied the effects of potential vaccines on these interferon-producing cells.
Canarypox-based vaccines induced higher levels of (gamma) (delta) T-cell activity compared with naked HIV coat protein, according to their report.
Worku and coworkers compared the effects of a live recombinant canarypox vector expressing HIV proteins with those of soluble recombinant HIV glycoprotein (gp)120 from the MN strain of the virus. Unlike rgp120, the canarypox-based vaccine triggered (gamma) (delta) T-cell responses that persisted through secondary in vitro expansion, they said.
Canarypox-induced (gamma) (delta) T-cell responses were specific for canarypox, study data showed but not mycobacterial or HIV antigens. Volunteers vaccinated with canarypox-based vaccines also demonstrated a significantly higher degree of natural killer (NK) cell expansions compared with those who received rgp120.
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Source: HighBeam Research, Canarypox-Based Vaccines Trigger (gamma) (delta) T-Cell Activity.