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Coimmunization Leads To Immune Response In Woodchuck Hepatitis Model.
2001 OCT 24 - (NewsRx.com & NewsRx.net) -- by Sonia Bell-Nichols, senior medical writer - Coimmunization with plasmids encoded for interleukin (IL)-12 appears to boost Th1 cytokine response and protective immunity in animals vaccinated with the core antigen of woodchuck hepatitis virus (WHV), which closely resembles hepatitis B virus (HBV).
Although animal vaccination with plasmids encoded for woodchuck hepatitis core antigen (pCw) stimulates the production of antigen-specific T cells, those cells produce insufficient levels of interferon (IFN)-(gamma) and do not effect viral immunity, the authors of a new study say. By coimmunizing animals with vectors containing IL-12, they have overcome that problem, according to a report in the October 2001 issue of Journal of Virology.
J. Ruiz headed the investigation team at the University of Navarra in Pamplona, Spain, that conducted the animal model investigation. After observing that gene gun immunization with pCw alone did not stimulate effective immune response, Ruiz and colleagues proceeded to coimmunize a second group of animals with pCw and plasmids encoded for woodchuck IL-12 (Protection against woodchuck hepatitis virus (WHV) infection by gene gun coimmunization with WHV core and interleukin-12, J Virol, October 2001;75(19):9068-9076).
"These animals exhibited woodchuck hepatitis core antigen (WHcAg) specific ...
- Coimmunization Leads To Immune Response In Woodchuck Hepatitis Model.(Brief...
- Newspaper article from: Immunotherapy Weekly October 24, 2001 700+ words
...vaccinated with the core antigen of woodchuck hepatitis virus (WHV), which...plasmids encoded for woodchuck hepatitis core antigen (pCw) stimulates...animals exhibited woodchuck hepatitis core antigen (WHcAg) specific...
- Adenovirus vectors and clevudine beat woodchuck hepatitis virus-infected cells.
- Newspaper article from: World Disease Weekly November 16, 2004 700+ words
...clevuidine beat woodchuck hepatitis virus-infected...therapy of chronic woodchuck hepatitis virus (WHV) infections...with detectable core antigen and nucleic acids...chronically infected with woodchuck hepatitis virus. Virology...
- Woodchuck hepatitis virus replication diminishes in preneoplastic lesions.
- Newspaper article from: Hepatitis Weekly November 11, 2002 700+ words
...virions, scientists have learned. Woodchuck hepatitis virus (WHV) infects animals such...containing the least or none at all (Woodchuck hepatitis virus replication and antigen expression...Hepatocellular carcinomas arising from woodchuck hepatitis virus (WHV) do not contain ...
- Genetics X Gene of Woodchuck Hepatitis Virus Characterized.
- Newspaper article from: Hepatitis Weekly November 9, 1998 700+ words
...promoter complex within thexgene of woodchuck hepatitis virus, according to a report from...additional promoters within the woodchuck hepatitis virus (WHV)xgene that stimulate...Promoter Complex Within thexGene of Woodchuck Hepatitis Virus," Virus Research, July...
- Immune-mediated clearance of neonatal woodchuck hepatitis virus falls short.
- Newspaper article from: Health & Medicine Week March 22, 2004 700+ words
...mediated clearance of neonatal woodchuck hepatitis virus falls short. According to...injury were studied during neonatal woodchuck hepatitis virus (WHV) infection in relation...relation to outcome of neonatal woodchuck hepatitis virus infection. J Med Virol...
- Virus-mediated alpha interferon transduction stops woodchuck hepatitis virus.
- Newspaper article from: Science Letter November 16, 2004 700+ words
...alpha interferon transduction stops woodchuck hepatitis virus. According to recent research...IFN-gamma(wIFN-gamma) on woodchuck hepatitis virus (WHV) replication in vivo...alpha but not IFN-gamma reduces woodchuck hepatitis virus replication in chronic infection...
- Interferon-gamma needs help to elicit a response to woodchuck hepatitis virus.
- Newspaper article from: Obesity, Fitness & Wellness Week November 20, 2004 700+ words
...needs help to elicit a response to woodchuck hepatitis virus. According to recent research...acute hepatitis and recovery from woodchuck hepatitis virus (WHV) infection involves...gamma-associated responses to woodchuck hepatitis virus infection in neonatal woodchucks...
- Low doses of woodchuck hepatitis virus target the lymphatic system.
- Newspaper article from: Biotech Week March 24, 2004 700+ words
2004 MAR 24 - (NewsRx.com & NewsRx.net) -- Low doses of woodchuck hepatitis virus target the lymphatic system. "Woodchuck hepatitis virus (WHV), which is closely related to human hepatitis B virus and is considered...
