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Vesicular Stomatitis Virus Vector Effective.
2001 OCT 24 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - A potential HIV vaccine using a modified vesicular stomatitis virus (VSV)-based vector has shown promise in animal studies, according to researchers in the United States.
"VSV vectors are promising candidates for human AIDS vaccine trials because they propagate to high titers and can be delivered without injection," explained John K. Rose, Yale University School of Medicine, and colleagues in a multicenter study.
Animals inoculated with a VSV-based vaccine displayed a high degree of protection from simian HIV (SHIV) infection, Rose and coauthors reported.
Rhesus monkeys were used to evaluate the efficacy of these vaccines. Priming immunization was achieved with attenuated VSV vectors engineered to express genes coding for the HIV proteins env and gag, with glycoproteins from a variety of VSV serotypes used for boosting, according to the report.
The seven inoculated animals were challenged with the extremely virulent simian HIV 89.6P (SHIV89.6P) strain. Despite acute infection, treated monkeys have maintained extremely low plasma SHIV RNA levels for more than a year after exposure, study data showed.
By contrast, untreated animals exposed to SHIV89.6P ...
- Vesicular stomatitis virus infusions staunch hepatocellular carcinoma in rats.
- Newspaper article from: Cancer Weekly May 11, 2004 700+ words
...NewsRx.net) -- Vesicular stomatitis virus infusions staunch hepatocellular...treatment of malignancy. Vesicular stomatitis virus (VSV) is a negative...hepatic artery infusion of vesicular stomatitis virus. Mol Ther, 2004;9...
- Alliance targets development of vesicular stomatitis virus-based...
- Newspaper article from: Vaccine Weekly February 26, 2003 700+ words
...announced that it has entered into a cross-license and commercial option agreement with Wyeth (WYE) for vesicular stomatitis virus (VSV)-based technologies. Wyeth has exclusively sublicensed to GTx patents covering VSV as cytolytic agents...
- Alliance targets development of vesicular stomatitis virus-based...
- Newspaper article from: Cancer Weekly February 25, 2003 700+ words
...announced that it has entered into a cross-license and commercial option agreement with Wyeth (WYE) for vesicular stomatitis virus (VSV)-based technologies. Wyeth has exclusively sublicensed to GTx patents covering VSV as cytolytic agents...
- Alliance targets development of vesicular stomatitis virus-based therapeutics.
- Newspaper article from: Biotech Week February 26, 2003 700+ words
...announced that it has entered into a cross-license and commercial option agreement with Wyeth (WYE) for vesicular stomatitis virus (VSV)-based technologies. Wyeth has exclusively sublicensed to GTx patents covering VSV as cytolytic agents...
- 'Anti-virus virus' to fight AIDS. (gp120 molecule developed from vesicular...
- Magazine article from: Chemistry and Industry September 15, 1997 700+ words
...hauls the virus in. Once inside, the virus kills the HIV-infected cell. The modified virus is based on the vesicular stomatitis virus (VSV), which normally infects livestock. Once inside HIV-infected cells, modified VSV replicates itself...
- GTx partners VSV technology with Wyeth.(GTx Inc., Wyeth-Ayerst Laboratories...
- Newspaper article from: BioWorld Week February 3, 2003 700+ words
...latter is the subject of CTx's first deal: It is teaming with Wyeth in an effort to further develop its vesicular stomatitis virus (VSV)-based technologies for use as targeted viral cytolytic agents against HIV-infected cells and cancers...
- Vesicular stomatitis found in Texas cattle.(Texas Animal Health...
- Magazine article from: Feedstuffs July 12, 2004 700+ words
AUSTIN, TEXAS -- This year's outbreak of vesicular stomatitis (VS) now has been confirmed not only in horses in Texas and New Mexico, but also in two head of cattle in Starr County, Texas...
- Reports from United States Department of Agriculture describe recent advances...
- Newspaper article from: Virus Weekly October 14, 2008 700+ words
...feeding behavior of vesicular stomatitis virus infected Culicoides sonorensis...To determine whether vesicular stomatitis virus (VSV) infection of...feeding behavior of vesicular stomatitis virus infected Culicoides sonorensis...
- U. Texas-Austin: Report says U. Texas students were near biological agents.
- News wire article from: The America's Intelligence Wire March 26, 2003 700+ words
...botulinum toxins [botulism], Shiga toxin, staphylococcal enter-otoxin and vesicular stomatitis virus. Only one of those agents -- vesicular stomatitis virus -- is "viable" for reproduction, according to the report. Erle Janssen, UT...
- Virus set against virus.
- Magazine article from: British Medical Journal Josefson, Debbie September 20, 1997 700+ words
...States using a defective vesicular stomatitis virus and a group from Germany...modified the genome of the vesicular stomatitis virus, replacing the genes...Once HIV is inside, the vesicular stomatitis virus destroys it. An additional...
Source: HighBeam Research, Vesicular Stomatitis Virus Vector Effective.