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2001 OCT 18 - (NewsRx.com & NewsRx.net) -- In migraine headaches preceded by auras, the aura itself likely triggers the pain, according to a study presented at the American Neurological Association's 126th annual meeting in Chicago.
"We establish, for the first time, a link between the aura, which is generated in the brain, and the pain of migraine, which is partially generated in membranes covering the brain," said lead author Hayrunnisa Bolay, MD, PhD, of Harvard University.
Migraine headaches are characterized by pulsing or throbbing pain in one area of the head and affect about 10% of the population, predominantly women. About one in five migraine sufferers can predict the recurrence of headache by an 'aura,' which typically involves visual changes, such as seeing lines, spots, or even hallucinations.
Auras have been convincingly tied to the brain phenomenon of cortical spreading depression (CSD), during which a wave of decreased brain cell activity crosses the cortex, the outermost part of the brain.
The pain of migraine, on the other hand, has been traced to inflammation and blood flow changes in the dura mater, a membrane that covers the brain, and specifically to stimulation of the trigeminal nerve pain system in this membrane.
Because the aura consistently precedes the pain of headache, many ...