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Inhaled Steroids Accelerate Bone Loss In Women.
2001 OCT 18 - (NewsRx.com & NewsRx.net) -- Premenopausal women who use inhaled corticosteroids to treat persistent asthma may experience accelerated bone loss in the hip compared with those who do not use inhaled steroids, according to results of a new study of 109 women ages 18 to 45 years old.
Researchers at Brigham and Women's Hospital (BWH) in Boston, Massachusetts, report that the effect of the inhaled steroids was directly related to the dose - that is, the bone density loss increased with the number of puffs per day and persisted throughout the three-year study.
Although the yearly changes were small, the scientists suggest that the long-term cumulative effect could ultimately put some women at high risk of hip fracture. The study was supported by the U.S. National Heart, Lung, and Blood Institute (NHLBI) and the National Center for Research Resources - both components of the National Institutes of Health.
Inhaled steroids are the recommended treatment for persistent asthma, according to NHLBI's 1997 Guidelines for the Diagnosis and Management of Asthma, because they reduce the airways' inflammation and sensitivity to certain irritants and allergens that contribute to asthma symptoms.
"As with all treatments, the goal is to maximize the benefits and minimize the risks," says NHLBI Director Dr. Claude Lenfant. "It is important to recognize that poor asthma control can lead to complications. Research has found repeatedly that compared to other medical therapies, inhaled steroids provide the best daily control of persistent asthma."
Measuring bone density at baseline, six months, and annually thereafter, the researchers compared the results among women who used inhaled triamcinolone acetonide, a steroid, at two dosage levels (four to eight puffs per day versus more than eight puffs per day) and those who did not use inhaled steroids. They found that those using the inhaled steroids had decreased bone density in the hip but not in the spine or femoral neck (part of the thigh leading to the hip). The rates of bone density loss varied among the women taking inhaled steroids, but the effects were greater with higher dosages and ...
- Inhaled Steroids and Bone Density.
- Newspaper article from: Pediatrics for Parents November 1, 1998 700+ words
...that is a part of asthma. But steroids can cause problems with bone density, and that's why doctors are often reluctant to use steroids on a long term basis. Inhaled steroids are frequently an important part of the treatment asthma, especially...
- Inhaled Steroids Accelerate Bone Loss In Women.(Brief Article)
- Newspaper article from: Immunotherapy Weekly October 17, 2001 700+ words
...those using the inhaled steroids had decreased bone density in the hip...The rates of bone density loss varied...women taking inhaled steroids, but the effects...the effect of inhaled steroids on bone density have been conflicting...
- INHALED STEROIDS MAY THIN BONES.(NEWS)
- Newspaper article from: The Cincinnati Post (Cincinnati, OH) September 27, 2001 700+ words
...Byline: Associated Press Inhaled steroids, widely used to treat asthma...relation between the amount of inhaled steroids used and a decrease in bone density in the 109 women studied...similar results in men who use inhaled steroids.
- INHALED STEROIDS AND INCREASED BONE LOSS.(Brief Article)
- Newspaper article from: HealthFacts Napoli, Maryann October 1, 2001 700+ words
...into three groups: no inhaled steroids, four to eight puffs a day of inhaled steroids, or eight or more puffs...between the decline in bone density and the number of puffs...use. Inexplicably, inhaled steroids caused bone loss at...
- Daily Inhaled Steroids Offer Net Benefits in Asthma.(Brief Article)
- Magazine article from: Family Practice News MOON, MARY ANN March 1, 2001 700+ words
...that in the other two groups. There were no differences among the three groups in bone age, Tanner stage, or changes in bone density. "At the end of the study children in the budesonide group were an average of 1 cm shorter than those in the other two...
- Breathing freely threatens seeing clearly. (inhaled steroids linked to glaucoma...
- Magazine article from: Science News Sternberg, Steve March 8, 1997 700+ words
...sigh of relief with the advent of inhaled steroids in the early 1990s. These widely...of oral steroids. So effective are inhaled steroids at staving off asthma attacks that...research indicates, however, that inhaled steroids may have an unsuspected dark side...
- Inhaled steroids produce variable benefits in the treatment of asthma.
- Newspaper article from: Immunotherapy Weekly May 15, 2002 700+ words
...demonstrated that low to medium doses of inhaled steroids are usually sufficient to improve...Increasing to high doses of the inhaled steroids failed to achieve greater improvement...those who will and will not respond to inhaled steroids. "Inhaled steroids have ...
- Inhaled steroids effective for moderate asthmatics.
- Newspaper article from: Asthma Management November 1, 1999 700+ words
Inhaled steroids effective for moderate asthmatics...asthma can get by on once-a-day inhaled steroids, whether it is Pulmicort or any...dose, Ford says. We know that inhaled steroids work best when divided into several...
