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Interleukin-2 Fusion Protein Enhances DNA Vaccine Effectiveness.(DNA tumor vaccine)
2001 OCT 17 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Researchers at Scripps Clinic and Research Institute in California have used a cytokine fusion protein to heighten the effectiveness of oral DNA vaccine against murine tumors.
Combination therapy, in effect, makes a good vaccine better. A.G. Niethammer and colleagues used a mouse-human antiganglioside GD2-interleukin (IL)-2 fusion protein (ch14, 18-IL2) to show that targeting IL-2 at the tumor microenvironment boosted immune response against murine melanoma when mice were administered oral DNA vaccines produced by fusing murine ubiquitin genes with murine melanoma peptide epitopes. Attenuated Salmonella typhimurium was used as the DNA vector.
"This combination therapy led to the complete rejection of a lethal challenge with B78D14 murine melanoma cells in six of eight mice and a marked suppression of subcutaneous tumor growth in the two remaining animals," described Niethammer and associates.
Both CD8[superscript]+ and CD4[superscript]+ T cells were activated following vaccination, according to researchers. They noted a cascade of events, including tumor necrosis factor (TNA)-alpha and interferon (IFN)-gamma secretion, ultimately leading to the ...
- Potency of suicidal DNA vaccine enhanced by delaying suicidal cell death.
- Newspaper article from: Immunotherapy Weekly March 17, 2004 700+ words
...Potency of a suicidal DNA vaccine was enhanced by delaying...encoding E7/BCL-xL fusion protein delayed cell death in...Enhancement of suicidal DNA vaccine potency by delaying...major subject areas of DNA Vaccine, Gene Therapy, Human...
- ADVAX, new DNA vaccine in human trial; HIV-negative volunteers needed in New...
- Newspaper article from: AIDS Treatment News James, John S. June 25, 2004 700+ words
...and most of them just inject the proteins. But ADVAX is a DNA vaccine; instead of providing the proteins directly, it provides...codes for five HIV genes (ENV, GAG, POL, and a NEF/TAT fusion protein). Other vaccines code for only one, two, or at most three...
- Immunomedics Develops New Fusion Protein with Improved Selectivity For Cancer...
- Press release article from: PR Newswire December 28, 1999 700+ words
...genetically engineered bispecific antibody fusion protein for use in a two-step drug delivery for cancer therapy. The new bispecific fusion protein was made by linking portions of genes...carrying a therapeutic agent. The fusion protein is half the size of a typical antibody...
- Dendritic cells pulsed with HIV TAT fusion protein induce antigen-specific CTLs.
- Newspaper article from: Proteomics Weekly March 24, 2003 700+ words
...DCs) pulsed with an HIV-derived fusion protein induce antigen-specific cytotoxic...advances in HIV trans-activating (TAT) fusion protein technology permit extremely high transduction...fusion technology." "A TAT-minigene fusion protein was generated, encoding both the HLA...
- StressGen reports data on recombinant fusion protein HspE7 mechanism of action.
- Press release article from: PR Newswire August 21, 2000 700+ words
...lead product, HspE7, a recombinant fusion protein, invokes a potent cytotoxic T cell...clearly indicate that the recombinant fusion protein is required for tumor regression and long-term survival. Components of the fusion protein, alone or in a mixture, are not effective...
- Daewoong obtains United States patent.(genetically engineered fusion...
- Newspaper article from: BIOTECH Patent News March 1, 2003 700+ words
...has patented a genetically engineered fusion protein consisting of hEGF that is internalized...internalization, a process for preparing a fusion protein in a large quantity by transforming...vectors containing the gene encoding the fusion protein, and pharmaceutical application of...
- Conotoxin MVIIA and thioredoxin fusion protein has analgesic activity.
- Newspaper article from: Biotech Week January 14, 2004 700+ words
...com & NewsRx.net) -- A fusion protein of conotoxin MVIIA and thioredoxin...expression vector pET-32a(+) and the fusion protein Trx-CTX MVIIA containing 6x His...determined by HPLC and the yield of the fusion protein was approximately 40 mg/L." "The...
- ZymoGenetics: Bristol-Myers Breaching Fusion Protein IP.
- Magazine article from: BIOWORLD Today Lorenzo, Aaron August 16, 2006 700+ words
...based company's immunoglobulin fusion protein technology. ZymoGenetics, which is...discovered by the company. A soluble fusion protein that links part of a cytokine receptor...that have access to ZymoGenetics' fusion protein technology include Amgen Inc. and...
Source: HighBeam Research, Interleukin-2 Fusion Protein Enhances DNA Vaccine Effectiveness.(DNA...