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Obese Young Women At Higher Mortality Risk From Carcinoma.(Brief Article)
2001 SEP 13 - (NewsRx.com & NewsRx.net) -- Among women diagnosed with breast carcinoma at age
According to the findings of this study, obesity as measured by being in the highest quartile of BMI is a strong predictor of mortality among young women with breast carcinoma. The results of the study demonstrate that the tumors in heavier women appear to be larger and more likely to have markers of high cellular proliferation compared with tumors in thinner women.
"The findings of our study, if confirmed by others, indicates that obesity as measured by BMI quartile is a strong predictor of mortality in women diagnosed with breast carcinoma before age 45 years," comments chief researcher Dr. Janet R. Daling, PhD, from the Fred Hutchinson Cancer Research Center in Seattle, Washington.
In prior studies, obesity has been shown to affect the prognosis of patients with breast carcinoma, with heavier women having a higher mortality rate compared with thinner women. However, to the authors' knowledge, few of these studies have focused on younger, largely premenopausal women or the correlation between BMI and tumor characteristics related to prognosis. The current study focused specifically on women age
The researchers investigated a total of 1777 women with invasive ductal breast carcinoma diagnosed between 1983 and 1992 in the Puget Sound area of western Washington State. All the women were under 45 years of age at diagnosis. Interviews were conducted with each patient to assess body size history including height and weight one year before diagnosis, maximum lifetime weight, and weight at age 18 years. The researchers used the Quetelet BM as the standard measure of obesity. For the purposes of the current analysis, BMI was based on the patient's weight one year before diagnosis.
Daling and colleagues observed that women with breast carcinoma whose BMI was within the highest quartile (>25.847) were 2.5 times more likely to die of their disease in the five years after diagnosis compared with women whose BMI was within the lowest quartile (
In addition, the findings indicate that women whose BMI was within the highest quartile were more likely to have tumors measuring 2 cm in size. The researchers reported that >66.6% of the women in the study whose BMI was within the highest quartile had tumors measuring 2 cm compared with 50.8% of the women whose BMI was within the other ...
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