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Hormone Replacement Therapy May Put Elderly Women At Risk.(Brief Article)
2001 SEP 13 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Hormone replacement therapy to ameliorate the effects of menopause may increase the risk of thrombotic disorders for elderly women, researchers in the United States warn.
"The effects of post-menopausal hormone therapy (HRT) on blood coagulation in elderly women are not well defined," according to Mary Cushman at the University of Vermont and colleagues at the University of Washington, the University of Pittsburgh, and Johns Hopkins University in Baltimore, Maryland.
Women over the age of 65 who used hormone replacement therapy had higher levels of procoagulant substances, and reduced levels of clot-dissolving substances, Cushman and coworkers found.
Data from their study showed that protein C, which is involved in clot formation, was present at significantly higher levels in women who used estrogen compared with untreated controls. Women who used estrogen in combination with progestin to decrease HRT-related cancer risks also showed a trend, albeit not statistically significant, toward higher protein C levels.
Moreover, levels of the anticoagulant antithrombin were significantly reduced in elderly women treated with hormone therapy. Antithrombin depletion was similar in women treated with estrogen alone or with progestin, Cushman and team noted.
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Source: HighBeam Research, Hormone Replacement Therapy May Put Elderly Women At Risk.(Brief...