AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Expanded Bone Marrow Can Improve Low-Dose Engraftment.(Brief Article)
2001 OCT 11 - (NewsRx.com & NewsRx.net) --
by Michael Greer, senior medical writer - A system for the ex vivo expansion of bone marrow can be used to improve the likelihood of stem cell engraftment after transplantation, researchers in the United States report.
"To reduce the number of apheresis procedures and maintain the usual rate of hematopoietic recovery in patients treated with high-dose chemotherapy, we studied the effect of adding a small volume of ex vivo expanded bone marrow to low doses of CD34(+) blood stem cells," explained Dr. A.L. Pecora and colleagues at the Hackensack University Medical Center and Progenitor Cell Therapy, L.L.C., in Hackensack, New Jersey; Loyola University in Maywood, Illinois; the Southwest Texas Cancer Institute in San Antonio; and Aastrom Biosciences in Ann Arbor, Michigan.
Pecora and coworkers found that expanded bone marrow could reduce stem cell collection requirements and increase the chances of successful transplantation.
A group of 34 breast cancer patients were treated with low-dose autologous stem cell infusions, supplemented with filgrastim and with bone marrow expanded using the AastromReplicell system. No patient required more than one apheresis session for stem cell harvesting, the researchers noted.
The researchers observed a significant correlation between the amount of stromal progenitor cells in expanded bone marrow infusions and the likelihood of successful stem cell engraftment (p=0.004). The only other variable linked to successful transplantation was the amount of lineage-negative ...
- Evaluation of the immature reticulocyte fraction as an early indicator for bone...
- Magazine article from: New Zealand Journal of Medical Laboratory Science Khor, Yeu-Sheuan November 1, 2008 700+ words
...transplants. Materials and Methods Bone marrow engraftment was evaluated...with disorders that required bone marrow/stem cell transplantation as a form...several days before their bone marrow or stem cell transplants and
- Cleveland BioLabs Protectan CBLB612 Produces Breakthrough in Bone Marrow Stem...
- Press release article from: PR Newswire May 21, 2007 700+ words
...Protectan CBLB612, in an animal bone marrow stem cell transplantation model. Blood...with radiation-induced bone marrow stem cell deficiency. 100 of the deficient...medicine." Adult hematological bone marrow stem cell transplantation is ...
- Aastrom Biosciences Forms European Clinical Network for Stem Cell Transplant...
- Press release article from: PR Newswire February 28, 2002 700+ words
...Aastrom's SC-I bone marrow stem cell product for use in...Norway. The SC-I bone marrow stem cell product is expected...bone marrow. The bone marrow is collected from...represents an adjunct for stem cell transplantation ...
- Aastrom Biosciences Receives Patent for Transplantation Use of Its Stem Cell...
- Press release article from: PR Newswire March 3, 2004 700+ words
...covers a method of bone marrow transplantation, often referred to as stem cell transplants, using...outside the body. Bone marrow stem cell transplants are used...or radiation. A bone marrow stem cell transplant typically...
- ThermoGenesis Announces Distribution Agreement for Bone Marrow Stem Cell Device.
- Press release article from: PR Newswire September 9, 2008 700+ words
...services in the evolving field of stem cell therapy. Celling Technologies will begin using the MXP to perform bone marrow stem cell separation for its existing point...separation of stem cells from bone marrow aspirate which is first to market...
- Treatment with Plerixafor Shown to Improve Mobilization of Cells in Donors...
- Newspaper article from: Clinical Oncology Week September 1, 2008 700+ words
...In a study of 25 bone marrow donors, treatment...associated with stem cell mobilization...used to collect bone marrow stem cells from...com Keywords: Bone Marrow, Cancer, Chest...Progenitor Cell, Stem Cell Research, Transplantation...
- Bone marrow and stem-cell features characterized in RA patients.
- Newspaper article from: Biotech Week May 12, 2004 700+ words
...Characteristic features of bone marrow and hematopoietic stem-cell populations have...hematopoietic stem-cell grafting...their study in Bone Marrow Transplantation...hematopoietic stem cell transplantation. Bone Marrow Transplant...
- Autologous bone-marrow stem-cell transplantation regenerates hearts.
- Newspaper article from: Heart Disease Weekly February 23, 2003 700+ words
...net) -- "Implantation of bone-marrow stem cells in the heart might...superscript]8 autologous AC133+ bone-marrow cells into the infarct border...study in Lancet (Autologous bone-marrow stem-cell transplantation for myocardial...
