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2001 OCT 11 - (NewsRx.com & NewsRx.net) --
A systematic review of randomized trials in the past two decades published in Lancet concludes that women given concurrent chemotherapy and radiotherapy for cervical cancer could have an increased survival rate compared with patients who get radiotherapy alone.
Cervical cancer is the second most common cancer affecting women and is the main cause of cancer mortality in less developed countries, according to the new Lancet study (Sept. 8, 2001, p. 781). Approximately 80% of women are treated with radiotherapy alone; however, the chemotherapeutic agent cisplatin is effective for treating metastatic cervical cancer, and is thought to enhance the effects of radiotherapy.
John Green and colleagues from Liverpool University, UK, reviewed the effects of combined chemotherapy and radiotherapy on overall and progression-free survival, local and distant disease control, and acute and late toxicity in patients with cervical cancer.
The investigators reviewed all known randomized ...