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Inherited Thrombophilia Not Linked To Development.(Brief Article)
2001 OCT 4 - (NewsRx.com & NewsRx.net) --
by Michael Greer, senior medical writer - Genetic predisposition to thrombotic disorders is not a risk factor for preeclampsia, a metabolic disorder experienced by some women in the latter stages of pregnancy, researchers in the United States report.
Dr. Baha M. Sibai and colleagues at the University of Cincinnati and the University of Tennessee conducted a study to "determine whether maternal or fetal genotype frequencies of the inherited thrombophilic gene mutations (factor V Leiden, methylenetetrahydrofolate, and prothrombin) are altered in severe preeclampsia."
No evidence was found suggesting a link between these polymorphisms and the development of preeclampsia, according to Sibai and coauthors.
Expectant mothers with the prothrombotic mutations studied were not significantly more likely than control patients to experience preeclampsia, which is characterized by swelling, high blood pressure, and proteinuria. Moreover, study data showed that fetal thrombotic disorders also had little or no effect on maternal preeclampsia risk.
Sibai and coworkers also investigated possible links between genetic thrombophilia risk factors and other disorders of pregnancy. However, they found no association between maternal or fetal thrombotic disorders and any such condition, including low platelet counts, intrauterine growth restriction, or full-fledged eclampsia ...
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Source: HighBeam Research, Inherited Thrombophilia Not Linked To Development.(Brief Article)