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Gene Variant Plays Role In 'Good' Cholesterol Levels.(Brief Article)
2001 OCT 4 - (NewsRx.com & NewsRx.net) --
Some individuals may have a clear advantage when it comes to keeping their bellies from sagging, according to researchers who have identified a genetic variation of a protein that may reduce the accumulation of body fat.
The study appears in Circulation: Journal of the American Heart Association.
The protein, called apolipoprotein A-II (apo A-II) is a major component of high-density lipoprotein (HDL), sometimes referred to as "good cholesterol" due to its role in reverse cholesterol transport, the process by which cholesterol molecules are transported from the blood vessels and other tissues to the liver. If this process is defective, cholesterol molecules can accumulate in the arteries, helping to clog them and raising the risk of heart attack and stroke. There is evidence that increased levels of apo A-II can lead to slower removal of cholesterol and, ultimately, more build-up in the arteries.
"Animal studies have shown that apo A-II not only plays a role in reverse cholesterol transport, but is also important in other processes related to fat metabolism. However, until now, little has been known about its significance in human metabolism," says lead researcher Ferdinand van 't Hooft, MD, PhD, of the Karolinska Institute, in Stockholm, Sweden. "This study provides the first evidence in humans for an extended role of apo A-II, in particular in relation to triglyceride and body fat accumulation."
The researchers studied the effect of specific variations of the apo A-II gene in a group of 624 ...
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Source: HighBeam Research, Gene Variant Plays Role In 'Good' Cholesterol Levels.(Brief Article)