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Lower Dose Of Mifepristone Effective When Used With Misoprostol.(Brief Article)
2001 OCT 4 - (NewsRx.com & NewsRx.net) --
A 100-milligram dose of mifepristone may be an effective alternative to larger doses of the drug when used with misoprostol for early pregnancy termination, according to the results of a recent study.
Previously, dosages of mifepristone given to women have ranged from 200 to 600 milligrams. Sold under the name Mifeprex, mifepristone was approved by the U.S. Food and Drug Administration for use in the United States. The drug is commonly known in Europe as RU-486, or the abortion pill. It is part of a regimen prescribed by doctors in many countries that includes misoprostol, an ulcer drug.
"The long-term benefit of the study shows that a lower effective dose of mifepristone could lower overall cost of treatment," said Mitchell Creinin, MD, lead study author and director of family planning in the department of obstetrics, gynecology, and reproductive sciences at the University of Pittsburgh School of Medicine, Pennsylvania. "Most importantly, this information provides more knowledge for future developments of antiprogestins."
The study was published in the September 2001 issue of the journal Obstetrics and Gynecology. In addition to Creinin, study authors included Helen C. Pymar, MD, and Jill L. Schwartz, MD.
Mifepristone blocks the hormone progesterone, which is necessary for an established pregnancy to continue. Misoprostol causes the uterus to contract and expel the fetus. The drug combination was approved in 1988 for use in France as an abortifacient. It has been used in Britain since 1991, and Sweden since 1992. It is only effective early ...
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