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Decline In Insulin Requirement Seen In Pregnant Diabetes Patients.(Type 1 Diabetes)(Brief Article)
2001 SEP 20 - (NewsRx.com & NewsRx.net) --
by Carol K. Kohn, MS, ELS(D), senior medical writer - The weekly insulin dose for the pregnant patient with diabetes should be reviewed carefully by her doctor, say researchers in California who saw those requirements decrease.
L. Javanovic and colleagues writing in Diabetes Care saw reduced insulin needs for women with type 1 diabetes who were in the middle of the first trimester. Their study included women participating in the Diabetes in Early Pregnancy Study (DIEP) who gave birth to full-term, single infants.
The researchers noted a statistically significant increase in insulin required between week 3 and week 7 (18%; p=0.000), but from week 7-15 another significant change, this time a decline, occurred (9%; p=0.000). "Further testing localized a significant change in insulin dose in the interval beginning weeks 7-8 and ending weeks 11-12 (p=0.014)," they added.
To try to determine whether poor diabetes management before pregnancy attributed to the changes noted, subjects were grouped according to baseline glycohemoglobin levels versus the normal population: <2 standard deviations above the mean, 2-4 SDs, and> 4 SDs. Late first trimester declines in insulin requirements were significant in the second group (p=0.002) and the combined second and third group (p=0.003). Women with body mass index greater than 27.0 had greater insulin requirement increase and then decrease than those with lower BMI, study data showed ("Declining insulin ...
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Source: HighBeam Research, Decline In Insulin Requirement Seen In Pregnant Diabetes...