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Antinicotine Vaccine TA-NIC Enters Phase I Trials.
2001 OCT 10 - (NewsRx.com & NewsRx.net) --
Xenova Group plc (XEN) has announced that its novel therapeutic vaccine, TA-NIC, which is being developed for the treatment of nicotine addiction, has entered Phase I clinical trials.
The Phase I study is a double-blind, randomized, placebo-controlled study to assess the safety, tolerability and immunogenicity of the TA-NIC vaccine in both smokers and non-smokers. The vaccine is administered by intra-muscular injection. In the first instance, two different dose levels are to be investigated in a variety of dosing regimens.
TA-NIC is believed to be the first antinicotine addiction vaccine to enter clinical testing. TA-NIC uses a novel mode of action whereby it seeks to prevent nicotine from entering the brain. Currently available therapies for nicotine addiction include nicotine replacement therapy, delivered via skin patches, chewing gum or inhalers or treatment with the nicotine-free drug bupropion.
Over one billion people worldwide smoke tobacco products according to the World Health Organization, resulting in approximately three ...
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