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Family Exposure To Hepatitis B Yields Faster Vaccine Immunity.(Brief Article)
2001 OCT 10 - (NewsRx.com & NewsRx.net) --
by Sonia Nichols, senior medical writer - Somehow, exposure to family members with chronic hepatitis B increases the rate at which other family members become immune to the virus after vaccination, investigators in Italy report.
According to V. Thakur and coworkers at G.B. Pant Hospital in New Delhi, India, hepatitis B virus (HBV) vaccination in exposed family members appears to boost the memory of their immune systems, causing those systems to respond faster than they ordinarily would have following immunization. Because some exposed family members also harbored HBV DNA that disappeared after vaccination, researchers also described immunization as being therapeutic.
Thakur and coworkers explained that the 79 family members who participated in the vaccine trial were healthy and negative for a viral marker denoting active infection, hepatitis B surface antigen (HBsAg). However, 25 of the family members had viral markers in their serum indicating previous exposure to HBV, and viral DNA was detected in 11 of those 25 individuals.
After just two doses of a multidose hepatitis B vaccine series, almost two-thirds of the exposed family members developed protection against the virus while a little over a third of unexposed family members did.
By the end of the trial, when all vaccines in the regular dosing ...
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